Results 181 to 190 of about 566,833 (345)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome [PDF]

, 2005
Mark Yandell, Adina Bailey, Sima Misra, Shengqiang Shu, C. van der Wiel, Martha Evans-Holm, S Celniker, Gerald M. Rubin   +7 more
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

FusionGDB 2.0: fusion gene annotation updates aided by deep learning. [PDF]

Nucleic Acids Res, 2022
Kim P, Tan H, Liu J, Lee H, Jung H, Kumar H, Zhou X.   +6 more
europepmc   +1 more source

Combining evidence, biomedical literature and statistical dependence: new insights for functional annotation of gene sets [PDF]

, 2006
Marc Aubry, Annabelle Monnier, Céline Chicault, Marie de Tayrac, Marie‐Dominique Galibert, Anita Burgun, Jean Mosser   +6 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

FertilityOnline: A Straightforward Pipeline for Functional Gene Annotation and Disease Mutation Discovery. [PDF]

Genomics Proteomics Bioinformatics, 2022
Gao J, Zhang H, Jiang X, Ali A, Zhao D, Bao J, Jiang L, Iqbal F, Shi Q, Zhang Y.   +9 more
europepmc   +1 more source

Articles selected by Faculty of 1000: Neurospora crassa genome sequence; human c-Myc target genes; prokaryote genome annotation database; diversity of marine eukaryotes; transcriptional regulation by a pseudogene

, 2003

openalex   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

GAPGOM-an R package for gene annotation prediction using GO Metrics. [PDF]

BMC Res Notes, 2021
van Mourik C, Ehsani R, Drabløs F.
europepmc   +1 more source