Results 191 to 200 of about 7,510,778 (382)

The Impact of Annotation on the Performance of Protein Tagging in Biomedical Text [PDF]

, 2006
In this paper we discuss five different corpora annotated for protein names. We present several within- and cross-dataset protein tagging experiments showing that different annotation schemes severely affect the portability of statistical protein taggers.
Alex, Beatrice, Grover, Claire, Nissim, Malvina   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Identification and Functional Annotation of Genes Related to Bone Stability in Laying Hens Using Random Forests [PDF]

, 2021
Simon Jansen, Ulrich Baulain, Christin Habig, Faisal Ramzan, Jens Schauer, Armin O. Schmitt, A. Scholz, Ahmad Sharifi, Annett Weigend, Steffen Weigend   +9 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Positively selected genes and their annotation

, 2022
Ziwei Wang
openalex   +1 more source

NCBI RefSeq: reference sequence standards through 25 years of curation and annotation.

Nucleic Acids Research
Reference sequences and annotations serve as the foundation for many lines of research today, from organism and sequence identification to providing a core description of the genes, transcripts and proteins found in an organism's genome.
Tamara Goldfarb, Vamsi K Kodali, S. Pujar, V. Brover, Barbara Robbertse, Catherine M. Farrell, Dong-Ha Oh, Alex Astashyn, O. Ermolaeva, Diana Haddad, W. Hlavina, J. Hoffman, John D. Jackson, V. Joardar, David M. Kristensen, Patrick Masterson, Kelly M. McGarvey, Richard McVeigh, Eyal Mozes, Michael R. Murphy, Susan S Schafer, Alexander Souvorov, Brett Spurrier, Pooja K. Strope, Hanzhen Sun, A. Vatsan, Craig Wallin, David Webb, J. R. Brister, Eneida L. Hatcher, Avi Kimchi, W. Klimke, Aron Marchler-Bauer, Kim D. Pruitt, F. Thibaud-Nissen, Terence D Murphy   +35 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Automatic Prediction and Annotation: There Are Strong Biases for Multigenic Families

Frontiers in Genetics, 2021
Catherine Mathé, Christophe Dunand
doaj   +1 more source

De novo transcriptome assembly and gene annotation for the toxic dinoflagellate Dinophysis. [PDF]

Sci Data, 2023
Gaonkar CC, Campbell L.
europepmc   +1 more source