Gene cassettes: a new class of mobile element [PDF]
Microbiology, 1995 G D, Recchia, R M, Hall
openaire +2 more sources
NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice
Advanced Science, EarlyView.In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu +15 more
wiley +1 more source
Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from Class 1 Integrons in Pseudomonas aeruginosa Strains. [PDF]
Microb Drug Resist, 2020 Liu M, Ma J, Jia W, Li W.
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Advanced Science, EarlyView.Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li +8 more
wiley +1 more source
The genetic context of blaIMP varies among bacterial families from One Health sources.
PLoS ONEThe blaIMP resistance gene encodes a metallo-beta-lactamase in bacteria, which confers reduced susceptibility or resistance to all the beta-lactams, including carbapenems which are critical for treating life-threatening infections.
Susan Vaughn Grooters +2 more
doaj +1 more source
MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
Integron gene cassettes harboring novel variants of D-alanine-D-alanine ligase confer high-level resistance to D-cycloserine. [PDF]
Sci Rep, 2020 Rahman MA +6 more
europepmc +1 more source
Promoters and control elements: Designing expression cassettes for gene therapy
, 2004 : It has become apparent that the clinical success anticipated in the field of gene therapy has been limited by progress in several of the fundamental areas of genetics, molecular and cellular biology relevant to its application.
Baker, AH +7 more
core
Engineered Optogenetic Circuits In Yeast with Self‐Sustained Outputs
Advanced Science, EarlyView.Optogenetic quorum‐sensing (OptoQS) circuit enables Saccharomyces cerevisiae to record transient light stimulus with self‐sustained outputs. Panel a indicates the design of the OptoQS circuit based on G‐protein coupled receptor (GPCR) signaling cascade. Panel b indicates the mode of action of surrogate messenger‐mediated signal transmission at the cell
Cong Fan +7 more
wiley +1 more source
Resistance integrons. Mini review
Caspian Journal of Internal Medicine, 2019 Integrons are a segment of dsDNA that play a major role in bacterial adaptation and evolution. These genetic determinants are known by the presence of three necessary apparatuses: an integrase (intI gene), Pc (a promoter) and attI (a recombination site).
Fariba Akrami +2 more
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