Results 121 to 130 of about 95,867 (295)

Methods for the targeted sequencing and analysis of integrons and their gene cassettes from complex microbial communities. [PDF]

Microb Genom, 2022
Ghaly TM, Penesyan A, Pritchard A, Qi Q, Rajabal V, Tetu SG, Gillings MR.   +6 more
europepmc   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Genetic Determinants of Antibacterial Resistance Among Nosocomial Escherichia coli Klebsiella spp., and Enterobacter spp. Isolates Collected in Russia within 2003-2007

Антибиотики и Химиотерапия, 2020
Nosocomial bacterial Isolates collected within 2003-2004 (n=411) and 2005-2007 (n=422) were highly resistant to cephalosporins III-IV and antibacterials of other groups (aminoglycosides, fluoroquinolons, chloramphenicol, and co-trimoxazole).
S. D. Pryamchuk, N. K. Fursova, I. V. Abaev, YU. N. Kovalev, N. A. Shishkova, E. I. Pecherskikh, O. V. Korobova, E. I. Astashkin, D. M. Pachkunov, A. N. Kruglov, D. V. Ivanov, S. V. Sidorenko, E. A. Svetoch, I. A. Dyatlov   +13 more
doaj  

Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping

Disease Models & Mechanisms, 2017
Gene trap mutagenesis is a powerful tool to create loss-of-function mutations in mice and other model organisms. Modifications of traditional gene trap cassettes, including addition of conditional features in the form of Flip-excision (FlEx) arrays to ...
Alexander Strassman, Frank Schnütgen, Qi Dai, Jennifer C. Jones, Angela C. Gomez, Lenore Pitstick, Nathan E. Holton, Russell Moskal, Erin R. Leslie, Harald von Melchner, David R. Beier, Bryan C. Bjork   +11 more
doaj   +1 more source

Introduction of Modified BglBrick System in Lactococcus lactis for Straightforward Assembly of Multiple Gene Cassettes. [PDF]

Front Bioeng Biotechnol, 2021
Plavec TV, Ključevšek T, Berlec A.
europepmc   +1 more source

Coordination of Cyanobacterial Nitrate Assimilation and Photosynthesis by a Novel PsbO‐Interacting Protein PirN

Advanced Science, EarlyView.
PirN was identified as a previously uncharacterized PsbO‐interacting protein specifically induced in nitrate‐grown cyanobacteria. Loss of PirN leads to coordinated downregulation of PsbO and the nitrate reductase NarB, causing decreased PSII activity and impaired growth under nitrate conditions. Complementation with either PsbO or NarB largely restores
Chengcheng Huang, Zhen Xiao, Haitao Ge, Gaojie Wang, Jinghui Dong, Yan Wang, Hang Yang, Xing Wang, Hui Gao, Zhongshu Wang, Huanling Yang, Yuanya Zhang, Xiahe Huang, Wu Xu, Weimin Ma, Wenqiang Yang, Yingchun Wang   +16 more
wiley   +1 more source

Construction of attenuated HIV-1 accessory gene immunization cassettes

Vaccine, 1998
Delivery of genetic expression cassettes into animals can effectively induce both humoral and cellular immunity to the expressed gene product. Previously, we used this strategy to immunize against HIV-1 structural and enzymatic proteins in mice, non-human primates and in humans.
V, Ayyavoo, T, Nagashunmugam, M T, Phung, C, Buckner, S, Kudckodkar, P, Le, P J, Reddy, L, Santiago, M, Patel, L, Tea, D B, Weiner   +10 more
openaire   +2 more sources

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

Advanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang, Jingrui Wang, Qiaowan Chen, Chen Jiao, Yun Chen, Zhongshou Wu, Zhonghua Ma   +6 more
wiley   +1 more source

Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

Virology Journal, 2009
Background Multiple short hairpin RNA (shRNA) gene therapy strategies are currently being investigated for treating viral diseases such as HIV-1. It is important to use several different shRNAs to prevent the emergence of treatment-resistant strains ...
Shen Sylvie W, Elliott Fiona A, Boyd Maureen P, Millington Michelle L, Arndt Allison J, Jaramillo Angel B, Tran Anna, Yu Yi-Hsin, Mcintyre Glen J, Murray John M, Applegate Tanya L   +10 more
doaj   +1 more source

Antimicrobial Resistance and Molecular Characterization of Gene Cassettes from Class 1 Integrons in Escherichia coli Strains. [PDF]

Microb Drug Resist, 2022
Li W, Ma J, Sun X, Liu M, Wang H.
europepmc   +1 more source