Results 111 to 120 of about 95,867 (295)

Transient Expression of Tetrameric Recombinant Human Butyrylcholinesterase in Nicotiana benthamiana. [PDF]

, 2016
To optimize the expression, extraction and purification of plant-derived tetrameric recombinant human butyrylcholinesterase (prBChE), we describe the development and use of plant viral amplicon-based gene expression system; Tobacco Mosaic Virus (TMV) RNA-
Alkanaimsh, Salem, Arzola, Lucas, Dandekar, Abhaya M, Falk, Bryce W, Guerrero, Andrés, Hashimoto, Bryce, Hwang, Min Sook, Karuppanan, Kalimuthu, Lebrilla, Carlito B, McDonald, Karen A, Nandi, Somen, Phu, My L, Rodriguez, Raymond L, Tu, Aye M   +13 more
core   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons.

PLoS Genetics
Integrons are adaptive devices that capture, stockpile, shuffle and express gene cassettes thereby sampling combinatorial phenotypic diversity. Some integrons called sedentary chromosomal integrons (SCIs) can be massive structures containing hundreds of ...
Egill Richard, Baptiste Darracq, Eloi Littner, Gael A Millot, Valentin Conte, Thomas Cokelaer, Jan Engelstädter, Eduardo P C Rocha, Didier Mazel, Céline Loot   +9 more
doaj   +1 more source

Analysis of antibiotic resistance gene cassettes in a newly identified Salmonella enterica serovar Gallinarum strain in Korea. [PDF]

Mob DNA, 2023
Tran TQ, Park M, Lee JE, Kim SH, Jeong JH, Choy HE.   +5 more
europepmc   +1 more source

Tertiary-Treated Municipal Wastewater is a Significant Point Source of Antibiotic Resistance Genes Into Duluth-Superior Harbor [PDF]

, 2011
In this study, the impact of tertiary-treated municipal wastewater on the quantity of several antibiotic resistance determinants in Duluth-Superior Harbor was investigated by collecting surface water and sediment samples from 13 locations in Duluth ...
Allen H. K., Alonso A., Amann R. I., Andersson D. I., Arthurson V., Auerbach E. A., Benson D. A., Berhardt A. E., Berhardt A. E., Canton R., Cardinale M., Chopra I., Cotner J. B., David T. Tan, Davies J., Diehl D. L., D’Costa V. M., Ghosh S., Graham D. W., Jessica J. Eichmiller, Levy S. B., Levy S. B., Ling L. L., Lipsitch M., Martínez J., Merlin C., Mi Yan, Moura A., Munir M., Nelson D. K., Novo A., Patrick J. McNamara, Pruden A., Ramsden S. J., Sambrook J., Seurinck S., Smith D. L., Sommer M. O. A., Staley J. T., Storteboom H., Tchobanoglous G., Thioulouse J., Thompson J. D., Timothy M. LaPara, Tucker R. Burch, Xi C., Yi L., Zhang T., Zhang X., Zhang X.-X.   +49 more
core   +3 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Identification and characterization of class 1 integrons among atypical enteropathogenic Escherichia coli isolated from children under 5 years of age

Iranian Journal of Microbiology, 2014
Background and Objectives: The therapeutic options for diseases caused by Escherichia coli are limited. In this study we investigated the presence of virulence factors among Enteropathogenic Escherichia coli (EPEC) strains and their antibiotic resistance
Farzad Shahcheraghi, Fatemeh Rahmati Ghezelgeh, Saman Nobari, Elham Torabi, Seyed-Fazlollah Mousavi, Mohammad Mehdi Aslani, Fereshteh Shahcheraghi   +6 more
doaj  

Prevalence, molecular characterization of integrons and its associated gene cassettes in Klebsiella pneumoniae and K. oxytoca recovered from diverse environmental matrices. [PDF]

Sci Rep, 2023
Fadare FT, Fadare TO, Okoh AI.
europepmc   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review

Microorganisms
Integrons, which are genetic components commonly found in bacteria, possess the remarkable capacity to capture gene cassettes, incorporate them into their structure, and thereby contribute to an increase in genomic complexity and phenotypic diversity ...
Niyaz Ali, Izhar Ali, Ahmad Ud Din, Kashif Akhtar, Bing He, Ronghui Wen   +5 more
doaj   +1 more source