Results 121 to 130 of about 838,531 (316)

Investigation of the role of t(4;6) and 6q15 deletion in prostate cancer development and progression

, 2010
PhDThe recent identification of TMPRSS2:ETS gene fusions highlighted the importance of chromosomal rearrangement and fusion gene development in prostate tumourigenesis.
Shan, Ling
core  

Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase

, 2006
Brockmann-Gretza O, Kalinowski J. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase. BMC Genomics.
Brockmann-Gretza Olaf, Kalinowski Jörn, Kalinowski, Jörn, Brockmann-Gretza, Olaf, Olaf Brockmann-Gretza, Jörn Kalinowski   +5 more
core   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Characterization and immunoprotective efficacy of a fumarate reductase frdA mutant of Salmonella enteritidis

Frontiers in Microbiology
BackgroundSalmonella has the ability to adapt to variable environments by modulating metabolism. The Tricarboxylic Acid Cycle (TCA), as a core metabolic process, is critical for the environmental adaptation and infection process of Salmonella.
Siping Zhu, Xinyi Sun, Xinyi Sun, Hong Li, Yongmei Su, Chihuan Li, Xintong Zhu, Chao Ren, Xiaochen Liu, Yulai Dong, Qiumei Shi, Zhiqiang Zhang   +11 more
doaj   +1 more source

Genomic Characterization of Orf Virus Strain D1701-V (Parapoxvirus) and Development of Novel Sites for Multiple Transgene Expression

Viruses, 2019
The Orf virus (ORFV; Parapoxvirus) strain D1701 with an attenuated phenotype and excellent immunogenic capacity is successfully used for the generation of recombinant vaccines against different viral infections.
Hanns-Joachim Rziha, Mathias Büttner, Melanie Müller, Ferdinand Salomon, Alena Reguzova, Dominic Laible, Ralf Amann   +6 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Impact of synonymous mutations in the blaTEM-3 gene on gene expression and Escherichia coli fitness

Microbiology Spectrum
Synonymous mutations (SMs) have a significant effect on the expression of the β-lactamase TEM-3 and the resistance phenotype conferred. Cell-free transcription did not reproduce this effect.
Rinku Dhungana, Heba Kaadan, Aparna Paudel, Peter Oelschlaeger   +3 more
doaj   +1 more source

Gene deletion analysis.

, 2019
(A) Heat map for single gene deletion (SGD) analysis for biomass precursors. (B) Heat map and table (C) for SGD analysis for 5 candidate metabolites along with glucose.
Deepanwita Banerjee (3964646), Anu Raghunathan (3964643)   +1 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Functional characterization of UL50 gene reveals its essential role in duck enteritis virus replication and pathogenesis

Veterinary Quarterly
Duck plague, caused by a highly contagious α-herpesvirus, poses a major threat to waterfowl farming. Although UL50 homologs have been studied in mammalian α-herpesviruses such as HSV-1 and PRV, their role in avian herpesviruses remains unknown.
Su-xin Huo, Liu Chen, En-dong Bao, Zheng Ni, Wei-cheng Ye, Jiong-gang Hua, Tao Yun, Yuan Fu, Yue Wu, Fang-zhou Ding, Xu Gao, Rui Zhong, Zong-xiao Wang, Cun Zhang, Yin-chu Zhu   +14 more
doaj   +1 more source