Results 141 to 150 of about 838,531 (316)

A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia

, 2010
Background: Abnormalities of 11q23 involving the MLL gene are found in approximately 10% of human leukemias. To date, nearly 100 different chromosome bands have been described in rearrangements involving 11q23 and 64 fusion genes have been cloned and ...
Meyer, Claus, Santos Joana, Claus Meyer, Lucília Norton, Susana Bizarro, Lisboa, Susana, Joana Santos, Cecília Correia, Lisboa Susana, Susana Lisboa, Meyer Claus, Teixeira Manuel R, Nuno Cerveira, Torres, Lurdes, Marschalek Rolf, Torres Lurdes, Norton Lucília, Correia, Cecilia, Pinheiro Manuela, Santos, Joana, Bizarro, Susana, Correia Cecília, Teixeira, Manuel R., Manuel R Teixeira, Pinheiro, Manuela, Cerveira Nuno, Marschalek, Rolf (Prof. Dr.), Rolf Marschalek, Lurdes Torres, Manuela Pinheiro, Cerveira, Nuno, Norton, Lucilia, Bizarro Susana   +32 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The mcpC mutant of Salmonella enteritidis exhibits attenuation and confers both immunogenicity and protective efficacy in mice

Frontiers in Microbiology
BackgroundSalmonella enteritidis (SE) is a Gram-negative, facultative anaerobic intracellular pathogen that not only causes disease and mortality in livestock and poultry but also contaminates animal-derived products, leading to foodborne illnesses in ...
Lu Zhang, Li Chen, Xuqiang Zhang, Yang Li, Qingfeng Zheng, Yun Li, Ning Li, Qiumei Shi, Yanying Zhang, Tonglei Wu   +9 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Pig-L mediates virulence, biofilm formation, and oxidative stress tolerance in Clostridioides difficile

Frontiers in Microbiology
BackgroundClostridioides difficile infection (CDI) represents a significant global public health concern. The Phosphatidylinositol Glycan Class L (pig-L) gene in C. difficile encodes an enzyme critical for the biosynthesis of Glycosylphosphatidylinositol
Yumei Cheng, Huilin Hu, Tingyu Huang, Xiang Luo, Fahui Chen, Peng Shi, Weihao Ma, Yingjun Lu, Siyu Lan, Guzhen Cui, Xiaolan Qi, Xiaolan Qi, Xiaolan Qi, Ya-Jun Liu, Ya-Jun Liu, Ya-Jun Liu, Wei Hong, Wei Hong, Wei Hong   +18 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Induction-free recombineering for simple targeted gene-deletions in various mycobacteria

Microbiology Spectrum
Gene deletion is a valuable tool for phenotypic characterization in bacteriology, but in mycobacteria, generating deletion mutants remains a cumbersome and time-consuming process.
Yahav Bracha, Daniel Barkan
doaj   +1 more source

Efficiency of gene deletion.

, 2018
Cells treated or untreated with HU were transformed with a pex10-deletion cassette with 50 bp of homology arm to the pex10 gene. The pex10 deletion rates (%) are shown and the number of total transformants screened is included in parentheses.
Byung Jo Yu (2208265), Jonggeon Jegal (4994501), Ji Yeon Jang (507002), Ju Young Lee (2481469), In-Seung Jang (4994504)   +4 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Gene Deletion [PDF]

, 2020
openaire   +1 more source