Results 191 to 200 of about 4,269,896 (304)

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

Extracellular Vesicles: A New Star for Gene Drug Delivery

Man Sun,1 Huan Zhang,1 Jiayi Liu,1 Jiayi Chen,1 Yaxin Cui,1 Simiao Wang,1 Xiangyu Zhang,2 Zhaogang Yang1 1School of Life Sciences, Jilin University, Changchun, 130012, People’s Republic of China; 2Department of General Surgery, Sir Run Run Shaw Hospital,
Sun M, Liu J, Yang Z, Chen J, Cui Y, Wang S, Zhang H, Zhang X   +7 more
core  

Noninvasive Focal Gene Delivery into the Cerebellum of Non-Human Primates using Focused Ultrasound. [PDF]

Adv Sci (Weinh)
Esteban-García N, Pineda-Pardo JA, Trigo-Damas I, Gutiérrez M, Castillo-Ortiz M, Carrillo M, Reinares-Sebastian A, Medina-Chavarrías V, Rachmilevitch I, Takada M, Obeso JA, Blesa J.   +11 more
europepmc   +1 more source

3D Bioprinted Glioblastoma Multiforme Models: How the Extracellular Matrix Glycosignature Influences Drug Response

Advanced Functional Materials, EarlyView.
Aberrant glycosylation in the glioblastoma tumor microenvironment drives therapeutic resistance. Here, a 3D bioprinted model was engineered by incorporating α‐NeuNAc‐(2→3)‐β‐D‐Gal‐ and chondroitin sulfate. Combined multiplex immunofluorescence and synchrotron‐based nanoCT analysis revealed that glycan‐matrix interactions dictate specific drug‐escape ...
Francesca Cadamuro, Marco Piazzoni, Ilaria Borghi, Alberto Baeri, Alessandro Fumagalli, Federica Perillo, Hafiz Muhammad Fahad, Martina Ghizzi, Luca Crippa, Gabriella Nicolini, Angela Bentivegna, Daniele Ramazzotti, Valentina Zuliani, Mirko Rivara, Carlo Giorgio Giussani, Andrea Di Cristofori, Guido Cavaletti, Federica Facciotti, Sobhan Sheikhi, Claire Seydoux, Murielle Salome, Peter Cloetens, Alberto Bravin, Paola Coan, Francesco Nicotra, Laura Russo   +25 more
wiley   +1 more source

Receptor-mediated gene delivery into mammalian cells [PDF]

, 1994
Kurt Zatloukal, Mechtler, Karl, Wagner, Ernst, Birnstiel, Max L., Ernst Wagner, Max L. Birnstiel, Cotten, Matt, Zatloukal, Kurt, Karl Mechtler, Spier, R. E., Matt Cotten, Plank, Christian, Christian Plank   +12 more
core   +1 more source

From LNPs to hybrid nanocarriers: development, challenges and redesign of non-viral gene delivery. [PDF]

J Nanobiotechnology
Wu W, Wei Z, Peng X.
europepmc   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Gene Delivery Mediated by Backbone-Degradable RAFT Copolymers. [PDF]

Biomacromolecules
Mulay PB, Radford DC, Rondon B, Favetta B, Schuster BS, Niu J, Gormley AJ.   +6 more
europepmc   +1 more source

Engineered Nanotopography to Modulate Growth and Signaling of Neuronal Networks

Advanced Functional Materials, EarlyView.
This study examines the interaction between neurons and nanoscale topographies on engineered substrates. Neurons cultured on nanowires, nanopillars and nanoneedles exhibit enhanced neurite outgrowth, form more organized neuronal circuits, and display improved synaptic connectivity, compared to flat substrates.
Hao Nguyen Tran, Kalyan Shobhana, Zlatan Trifunovic, Dan Smith, Michael Stuiber, Chennupati Jagadish, Mirella Dottori, Andrea J. O'Connor, Vini Gautam   +8 more
wiley   +1 more source

Copolymers of NVAm and NVP for Efficient Gene Delivery. [PDF]

ACS Polym Au
Fielitz T, Raab C, Tkachenko V, Oleszkiewicz KM, Fuchs H, Hartlieb M.   +5 more
europepmc   +1 more source