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Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Expert Opinion on Drug Delivery, 2020 Introduction Gene delivery technologies are being developed for an increasing number of biomedical applications, with delivery vehicles including viruses and non-viral materials.
J. Karlsson +3 more
semanticscholar +1 more source
Gene Therapy for Cardiovascular Disease [PDF]
, 2003 The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H. +3 more
core +9 more sources
Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy
Nanomaterials, 2021 The anti-metabolite drug gemcitabine is widely used for the treatment of a variety of cancers. At present, gemcitabine is administered as a hydrochloride salt that is delivered by slow intravenous injection in cycles of three or four weeks.
Saffiya Habib, Moganavelli Singh
doaj +1 more source
Biodegradable Polymers for Gene-Delivery Applications
International Journal of Nanomedicine, 2020 Gene-based therapies have emerged as a new modality for combating a myriad of currently incurable diseases. However, the fragile nature of gene therapeutics has significantly hampered their biomedical applications.
Chih-Kuang Chen +5 more
semanticscholar +1 more source
Scientific Reports, 2018 With the increasing demand for higher gene carrier performance, a multifunctional vector could immensely simplify gene delivery for disease treatment; nevertheless, the current non- viral vectors lack self-tracking ability.
Xia Cao +13 more
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Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy
Pharmaceutics, 2021 With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of ...
Thashini Moodley, Moganavelli Singh
doaj +1 more source
Ultrasound-Responsive Materials for Drug/Gene Delivery
Frontiers in Pharmacology, 2020 Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature.
Xiaowen Cai +7 more
semanticscholar +1 more source
Nanomaterials, 2021 Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys.
Femi Olawale +2 more
doaj +1 more source
Magnetofection potentiates gene delivery to cultured endothelial cells [PDF]
, 2003 Modification of cellular functions by overexpression of genes is increasingly practised for research of signalling pathways, but restricted by limitations of low efficiency. We investigated whether the novel technique of magnetofection (MF) could enhance
Gloe, Torsten +4 more
core +1 more source
Advances in Polymer Technology, 2019 An innovative strategy for the generation of chondrocytes was thoroughly studied in this paper. Polyetherimide-modified polysaccharides of Porphyra yezoensis (pmPPY) served as a nonviral gene vector and delivered Sox9 plasmid to directly reprogram mouse ...
Qingtong Yu +6 more
doaj +1 more source