Results 31 to 40 of about 8,692,782 (389)
Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]
, 2016 Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T +14 more
core +7 more sources
Pharmaceutical Applications of Molecular Tweezers, Clefts and Clips
Molecules, 2019 Synthetic acyclic receptors, composed of two arms connected with a spacer enabling molecular recognition, have been intensively explored in host-guest chemistry in the past decades.
Amira Mbarek +2 more
doaj +1 more source
Pharmaceuticals, 2023 Glioblastoma is a highly invasive and fatal disease. Temozolomide, a blood–brain barrier (BBB)-penetrant therapeutic agent currently used for glioblastoma, does not exhibit sufficient therapeutic effect.
Fumiko Hagiwara +6 more
doaj +1 more source
Chloroquine-enhanced gene delivery mediated by carbon nanotubes [PDF]
, 2011 Polyethyleneimine-coated double-walled carbon nanotubes (DWCNTs) were used for dual gene and drug delivery, after loading the DWCNTs with the drug chloroquine, a lysosomotropic compound that is able to promote escape from the lysosomal compartment ...
Borowiak-Palen +44 more
core +2 more sources
Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis [PDF]
, 2012 The nucleocytoplasmic partitioning of nanoparticles as a result of cell division is highly relevant to the field of nonviral gene delivery. We reviewed the literature on the intracellular distribution of cell organelles (the endosomal vesicles, Golgi ...
Braeckmans, Kevin +5 more
core +1 more source
Pharmaceutics, 2019 ：6-shogaol is a promising anti-cancer and anti-inflammatory agent. However, the treatment effectiveness of 6-shogaol is limited by poor water solubility, poor oral absorption and rapid metabolism.
Huiyun Zhang +10 more
doaj +1 more source
Recent Advances in Lipid-Based Nanosystems for Gemcitabine and Gemcitabine–Combination Therapy
Nanomaterials, 2021 The anti-metabolite drug gemcitabine is widely used for the treatment of a variety of cancers. At present, gemcitabine is administered as a hydrochloride salt that is delivered by slow intravenous injection in cycles of three or four weeks.
Saffiya Habib, Moganavelli Singh
doaj +1 more source
Hematology/Oncology Clinics of North America, 1998 Human gene therapy continues to be an exciting concept for the treatment of disease. This field of research remains in its early stages, but already a number of studies have provided "proof-of-principle." Although there is no unequivocal evidence of efficacy, there have been demonstrated physiologic changes that are relevant to the disease process. One
James M. Wilson, Nelson A. Wivel
openaire +3 more sources
Vectors and Gene Delivery to the Retina [PDF]
Annual Review of Vision Science, 2017 One of the great advantages of the retina as a target tissue for gene delivery is the wide array of genetic tools that have been developed in the past decade. This includes a variety of vectors for therapeutic gene delivery to most types of retinal neurons and glia, as well as cell type–specific promoters for restricted gene expression in distinct ...
Planul, Arthur, Dalkara, Deniz
openaire +4 more sources
Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo. [PDF]
, 2018 Engineering of the Cpf1 crRNA has the potential to enhance its gene editing efficiency and non-viral delivery to cells. Here, we demonstrate that extending the length of its crRNA at the 5 end can enhance the gene editing efficiency of Cpf1 both in cells
Chong, Anthony +10 more
core +2 more sources