Results 121 to 130 of about 408,305 (347)

Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release [PDF]

, 2011
Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug ...
A Al-Omar, A Latrofa, A Miro, A Trapani, A Vyas, AC Jain, AK Upadhyay, AL Nielsen, AS Hoffman, B Haeberlin, B Pose-Vilarnovo, BN Naidu, C Cannavà, C Rodriguez-Tenreiro, C Rupp, C-Y Chen, Catarina Carvalho, Claúdia Conduto, CM Buchanan, CM Fernandes, D Duchêne, D Duchêne, EA Zannou, EY Kim, F Frézard, F Hirayama, G Corti, G Gladys, G Pescitelli, G Trapani, G Wenz, G Zingone, GL Amidon, H Blode, H Hamada, H Matsuda, H Namazi, H Taira, H Yano, HA Archontaki, Helena M. Cabral Marques, HH Sigurdsson, HS Ganapathy, HS Woldum, Inês Sanches, IV Terekhova, J Cheng, J Králová, J Savolainen, J Szejtli, J Szejtli, J Xiong, JJ García-Rodriguez, João Arrais, JP Venter, JR Moyano, JS Smith, JW Wong, K Dua, K Minami, K Motoyama, K Nakanishi, K Okimoto, K Okimoto, K Okimoto, K Terao, K Udo, K Uekama, K Uekama, K Uekama, K-H Frӧmming, KP Chowdary, L Ribeiro, L Szente, L Trichard, M Agüeros, M Agüeros, M Charoenchaitrakool, M Cirri, M Echezarreta-López, M Fukuda, M Jug, M Jug, M Kamada, M Prabaharan, M Roux, M Sauceau, M Temtem, M Türk, M Usuda, M Yoshinari, M-J Zou, ME Zugasti, MT Esclusa-Díaz, MZI Khan, N Mourtzis, N Patel, N Zerrouk, N Zhang, N Özdemir, P Jansook, P Mura, P Mura, P Mura, P Mura, P Mura, Patrícia Pontes, Paulo José Salústio, PJ Salústio, R Cavalli, R Cavalli, R Challa, R Ficarra, R Garg, R Stancanelli, RL Carrier, S Petralito, S Péroche, S Sajeesh, S Sotthivirat, S Sotthivirat, S Szejtli, S Tommasini, S-Y Lee, Shishu, SM Badr-Eldin, T Endo, T Higashi, T Higashi, T Irie, T Loftsson, T Loftsson, T Loftsson, T Vasconcelos, T Yamanoi, V Burckbuchler, V Lemesle-Lamache, VM Rao, W Ling, W Sajomsang, X Lu, X Wen, X-M Liu, Y He, Y Ikeda, Y Ikeda, Y Liu, Y Liu, Y Lu, Y Tozuka, Y Zhou, Y-Z Du, Z Lu, Z Wang   +153 more
core   +1 more source

Identification of X-chromosomal genes that drive global X-dosage effects in mouse embryonic stem cells [PDF]

, 2020
Oriana Genolet, Anna A. Monaco, Ilona Dunkel, Michael Boettcher, Edda G. Schulz   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Gene expression analysis identifies global gene dosage sensitivity in cancer

Nature Genetics, 2015
Many cancer-associated somatic copy number alterations (SCNAs) are known. Currently, one of the challenges is to identify the molecular downstream effects of these variants. Although several SCNAs are known to change gene expression levels, it is not clear whether each individual SCNA affects gene expression.
Rudolf S N Fehrmann, Juha M Karjalainen, Małgorzata Krajewska, Harm-Jan Westra, David Maloney, Anton Simeonov, Tune H Pers, Joel N Hirschhorn, Ritsert C Jansen, Erik A Schultes, Herman H H B M van Haagen, Elisabeth G E de Vries, Gerard J te Meerman, Cisca Wijmenga, Marcel A T M van Vugt, Lude Franke   +15 more
openaire   +3 more sources

Caracterización del perfil quimiosensibilidad y del estado de ampliación génica de un panel de líneas celulares de origen tumoral pulmonar

Revista Colombiana de Biotecnología, 2013
Título en Ingles: Characterization of chemosensitivity profile and gene amplification status of a panel of lung cancer cell linesTítulo Corto: Amplificación génica y quimiosensibilidad en líneas celulares de cáncer de pulmónResumen: En este trabajo se ...
Sandra Johanna Morantes, Sandra Perdomo, Edward Fabián Carrillo, Fabio Aristizábal   +3 more
doaj  

Gene Dosage Effects at the Imprinted Gnas Cluster.

PLoS ONE, 2013
Genomic imprinting results in parent-of-origin-dependent monoallelic gene expression. Early work showed that distal mouse chromosome 2 is imprinted, as maternal and paternal duplications of the region (with corresponding paternal and maternal ...
Simon T Ball, Michelle L Kelly, Joan E Robson, Martin D Turner, Jackie Harrison, Lynn Jones, Diane Napper, Colin V Beechey, Tertius Hough, Antonius Plagge, Bruce M Cattanach, Roger D Cox, Jo Peters   +12 more
doaj   +1 more source

Why genes evolve faster on secondary chromosomes in bacteria [PDF]

, 2010
In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary.
Cooper, Vaughn S., Hatcher, Philip J., Vohr, Samuel H., Wrocklage, Sarah C.   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1 [PDF]

, 2019
Qi Yin, Hongye Wang, Zhenfei Xie, Lifang Jin, Yifu Ding, Na Li, Yan Li, Qiong Wang, Xinyi Liu, Liu‐Qing Xu, Kai Wang, Yanbo Cheng, Boran Chang, Cuiqing Zhong, Yu Qian, Wei Tang, Wan‐Jin Chen, Wenjun Yang, Fan Zhang, Chen Ding, Lan Bao, Bin Zhou, Ping Hu, Jinsong Li   +23 more
openalex   +1 more source

Escaping But Not the Inactive X-Linked Protein Complex Coding Genes May Achieve X-Chromosome Dosage Compensation and Underlie X Chromosome Inactivation-Related Diseases

, 2022
Zhihao Xing, Yuchao Zhang, Meng Wang, Weiwei Xiao, Chunqing Zhu, Songhui Zhao, Yufei Zhu, Landian Hu, Xiangyin Kong   +8 more
openalex   +1 more source