Results 121 to 130 of about 252,745 (293)

Supplementary Data from Clinical Implications of Gene Dosage and Gene Expression Patterns in Diploid Breast Carcinoma

, 2010
Supplementary Data from Clinical Implications of Gene Dosage and Gene Expression Patterns in Diploid Breast ...
Anna Danielsson (172641), Anikó Kovács (291830), Elin Möllerström (14982917), Toshima Z. Parris (8459544), Szilárd Nemes (4178380), Ulla Delle (14982911), Ghita Fallenius (14982914), Per Karlsson (48671), Khalil Helou (561963)   +8 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Caracterización del perfil quimiosensibilidad y del estado de ampliación génica de un panel de líneas celulares de origen tumoral pulmonar

Revista Colombiana de Biotecnología, 2013
Título en Ingles: Characterization of chemosensitivity profile and gene amplification status of a panel of lung cancer cell linesTítulo Corto: Amplificación génica y quimiosensibilidad en líneas celulares de cáncer de pulmónResumen: En este trabajo se ...
Sandra Johanna Morantes, Sandra Perdomo, Edward Fabián Carrillo, Fabio Aristizábal   +3 more
doaj  

The relationship among gene expression, the evolution of gene dosage, and the rate of protein evolution.

, 2010
The understanding of selective constraints affecting genes is a major issue in biology. It is well established that gene expression level is a major determinant of the rate of protein evolution, but the reasons for this relationship remain highly debated.
Daniel Kahn, Kahn, Daniel, Duret, Laurent, Paramecium Post-Genomics Consortium, Duret Laurent, Jean-François Gout, Laurent Duret, Kahn Daniel, Gout, Jean-François, Gout Jean-François   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular basis of gene dosage sensitivity

, 2009
Deviation of gene expression from normal levels has been associated with diseases. Both under- and overexpression of genes could lead to deleterious biological consequences.
Chen, Jianping
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Single cell transcriptome in aneuploidies reveals mechanisms of gene dosage imbalance

Nature Communications, 2019
Gene dosage anomalies such as those caused by aneuploidy underlie diseases including Down syndrome. Here, the authors perform allele-specific single cell transcriptome analysis to investigate the mechanisms of gene dosage imbalance in fibroblasts with ...
Georgios Stamoulis, Marco Garieri, Periklis Makrythanasis, Audrey Letourneau, Michel Guipponi, Nikolaos Panousis, Frédérique Sloan-Béna, Emilie Falconnet, Pascale Ribaux, Christelle Borel, Federico Santoni, Stylianos E. Antonarakis   +11 more
doaj   +1 more source

Development and validation of a taqman multiplex pcr assay for the gene dosage quantification in cancer [PDF]

, 2012
Gene dosage tests are very important for the molecular diagnosis of diseases caused by either deletion or amplification of a specific DNA region containing certain genes.
Perdomo Lara, Sandra Janeth, Aristizábal Gutiérrez, Fabio Ancízar, Morantes, Sandra Johanna   +2 more
core