Results 141 to 150 of about 7,162,706 (382)
, 2020 X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Mutzel, V., Schulz, E.
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Evolution of gene dosage on the Z-chromosome of schistosome parasites
eLife, 2018 XY systems usually show chromosome-wide compensation of X-linked genes, while in many ZW systems, compensation is restricted to a minority of dosage-sensitive genes. Why such differences arose is still unclear. Here, we combine comparative genomics, transcriptomics and proteomics to obtain a complete overview of the evolution of gene dosage on the Z ...
Picard, Marion +6 more
openaire +6 more sources
Loss of redundant gene expression after polyploidization in plants
, 1978 Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25 ...
C. Aragoncillo +20 more
core +1 more source
BMC Evolutionary Biology, 2016 Dosage balance has been described as an important process for the retention of duplicate genes after whole genome duplication events. However, dosage balance is only a temporary mechanism for duplicate gene retention, as it ceases to function following ...
Ashley I. Teufel, Liang Liu, D. Liberles
semanticscholar +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Ts66Yah, a mouse model of Down syndrome with improved construct and face validity
Disease Models & Mechanisms, 2022 Arnaud Duchon +11 more
doaj +1 more source
Dosage compensation can buffer copy-number variation in wild yeast
eLife, 2015 Aneuploidy is linked to myriad diseases but also facilitates organismal evolution. It remains unclear how cells overcome the deleterious effects of aneuploidy until new phenotypes evolve. Although laboratory strains are extremely sensitive to aneuploidy,
James Hose +5 more
doaj +1 more source
THE ACTION OF ALLELIC FORMS OF THE GENE A IN MAIZE. I. STUDIES OF VARIABILITY, DOSAGE AND DOMINANCE RELATIONS. THE DIVERGENT CHARACTER OF THE SERIES [PDF]
, 1948 John R. Laughnan
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source