Results 11 to 20 of about 408,305 (347)
eLife, 2022 Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes.
Sean Akira Montgomery +7 more
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Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?
Frontiers in Cellular and Infection Microbiology, 2021 Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado +3 more
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Gene Dosage by Quantitative Real-Time PCR
BioTechniques, 1999 J.-L. Boulay +5 more
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Photoreactivation and Gene Dosage in Yeast [PDF]
Journal of Bacteriology, 1972 The amount of photoreactivating enzyme in tetraploid cells of Saccharomyces cerevisiae and the ability of the cells to be photoreactivated after ultraviolet irradiation are directly proportional to the number of genes per cell involved in the synthesis of photoreactivating enzyme.
M A, Resnick, J K, Setlow
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From Klinefelter Syndrome to High Grade Aneuploidies: Expanding the Gene-dosage Effect of Supernumerary X Chromosomes. [PDF]
J Clin Endocrinol MetabSpaziani M +10 more
europepmc +2 more sources
Biomédica: revista del Instituto Nacional de Salud, 2000 Se identificaron 7 mujeres portadoras y 15 no portadoras de deleción en 16 familias con distrofia muscular de Duchenne o de Becker (DMDIDMB) mediante PCR multiplex cuantitativa y análisis de dosis génica. Los afectados con DMDIDMB mostraron deleciones en
Patricia Hernández +2 more
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Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
Cells, 2022 Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri +2 more
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Gene dosage analysis in Azotobacter vinelandii. [PDF]
Genetics, 1992 Abstract For more than a decade, Azotobacter vinelandii has been considered a polyploid bacterium on the basis of physical studies of chromosome size and DNA content per cell. However, as described in the present work, many genetic operations can be performed in A. vinelandii without the constraints expected in a polyploid bacterium: (i)
Maldonado Caro, Rafael Diego +3 more
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Disease Models & Mechanisms, 2021 Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions.
Leticia L. Niborski +12 more
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DNA Methylation Rebalances Gene Dosage after Mammalian Gene Duplications [PDF]
Molecular Biology and Evolution, 2011 Although gene duplication plays a major role in organismal evolution, it may also lead to gene dosage imbalance, thereby having an immediate adverse effect on an organism's fitness. Investigating the evolution of the expression patterns of genes that duplicated after the divergence of rodents and primates, we confirm that adaptive evolution has been ...
Andrew Ying-Fei, Chang, Ben-Yang, Liao
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