Results 11 to 20 of about 252,745 (293)
Frontiers in Plant Science, 2016 Gene/genome dosage balance is an essential evolutionary mechanism for organisms to ensure a normal function, but the underlying causes of dosage-imbalance regulation remain poorly understood.
Chen Tan +5 more
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DOSAGE COMPENSATION: REGULATION OF SEX CHROMOSOME GENE EXPRESSION
Вавиловский журнал генетики и селекции, 2014 Dosage compensation is observed in various taxa of organisms with heteromorphic sex chromosomes. Dosage compensation mechanisms are thought to have arisen to eliminate differences in gene dosage between sexes that appeared in the course of sex chromosome
E. V. Dementyeva
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A Quantitative Perspective of Alpha-Synuclein Dynamics – Why Numbers Matter
Frontiers in Synaptic Neuroscience, 2021 The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties.
Christian G. Specht
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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng, Qian, Jianzhi, Zhang
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Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?
Frontiers in Cellular and Infection Microbiology, 2021 Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado +3 more
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Photoreactivation and Gene Dosage in Yeast [PDF]
Journal of Bacteriology, 1972 The amount of photoreactivating enzyme in tetraploid cells of Saccharomyces cerevisiae and the ability of the cells to be photoreactivated after ultraviolet irradiation are directly proportional to the number of genes per cell involved in the synthesis of photoreactivating enzyme.
M A, Resnick, J K, Setlow
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eLife, 2022 Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes.
Sean Akira Montgomery +7 more
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Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
Cells, 2022 Aneuploidy is a cellular state with an unbalanced chromosome number that deviates from the usual euploid status. During evolution, elaborate cellular mechanisms have evolved to maintain the correct chromosome content over generations.
Narendra Kumar Chunduri +2 more
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Biomédica: revista del Instituto Nacional de Salud, 2000 Se identificaron 7 mujeres portadoras y 15 no portadoras de deleción en 16 familias con distrofia muscular de Duchenne o de Becker (DMDIDMB) mediante PCR multiplex cuantitativa y análisis de dosis génica. Los afectados con DMDIDMB mostraron deleciones en
Patricia Hernández +2 more
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Disease Models & Mechanisms, 2021 Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions.
Leticia L. Niborski +12 more
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