Results 191 to 200 of about 7,614,096 (384)

TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

Genetics in Medicine, 2019
Jiaqi Liu, N. Wu, Nan Yang, K. Takeda, Weisheng Chen, Weiyu Li, Renqian Du, Sen Liu, Yangzhong Zhou, Ling Zhang, Zhenlei Liu, Yuzhi Zuo, Sen Zhao, R. Blank, D. Pehlivan, Shuangshuang Dong, Jianguo Zhang, Jianxiong Shen, Nuo Si, Yi‐peng Wang, Gang Liu, Shugang Li, Yanxue Zhao, Hong Zhao, Yi-Xin Chen, Yu Zhao, Xiaofei Song, Jianhua Hu, Mao Lin, Ye Tian, Bo Yuan, K. Yu, Y. Niu, Bin Yu, Xiaoxin Li, Jia Chen, Zihui Yan, Qian-kun Zhu, Xiaolu Meng, Xiaoli Chen, Jianzhong Su, Xiuli Zhao, Xiaoyue Wang, Y. Ming, Xiao Li, C. Raggio, Baozhong Zhang, X. Weng, Shuyang Zhang, Xue Zhang, Kota Watanabe, M. Matsumoto, Li Jin, Yiping Shen, Nara Sobreira, J. Posey, P. Giampietro, D. Valle, Pengfei Liu, Zhihong Wu, S. Ikegawa, J. Lupski, Feng Zhang, G. Qiu, D. D. D. Study, Japan Early Onset Scoliosis Research Group, Baylor-Hopkins Center for Mendelian Genomics   +66 more
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

H4K20me1 Contributes to Downregulation of X-Linked Genes for C. elegans Dosage Compensation

, 2020
Anne Vielle, Jackie Lang, Yan Dong, Sevinç Ercan, Chitra V. Kotwaliwale, Andreas Rechtsteiner, Alex Appert, Q. Brent Chen, Andrea C. Dosé, Thea A. Egelhofer, Hiroshi Kimurâ, Przemysław Stempor, Abby F. Dernburg, Jason D. Lieb, Susan Strome, Julie Ahringer   +15 more
openalex   +1 more source

Mutants of bacteriophage T4 deficient in the ability to induce nuclear disruption: shutoff of host DNA and protein synthesis gene dosage experiments, identification of a restrictive host, and possible biological significance [PDF]

, 1976
D. Peter Snustad, C J Bursch, Kathleen A. Parson, Steven H. Hefeneider   +3 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Effect of Cyp27A1 gene dosage on atherosclerosis development in ApoE‐knockout mice

, 2013
Line Zurkinden, Curzio Solcà, Isabelle Vögeli, Bruno Vogt, Daniel Ackermann, Sandra K. Erickson, Felix J. Frey, Dmitri Sviridov, Geneviève Escher   +8 more
openalex   +1 more source

Review for "A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma"

, 2022
Marazziti Daniela
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche [PDF]

, 2018
Eric D. Bankaitis, Matthew E. Bechard, Guoqiang Gu, Mark A. Magnuson, Christopher V.E. Wright   +4 more
openalex   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source