Results 191 to 200 of about 7,162,706 (382)

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Sex Chromosome Dosage Compensation in Insects

Insects
Dosage compensation (DC) is of crucial importance in balancing the sex-linked gene expression between males and females. It serves to guarantee that the proteins or other enzymatic products encoded by the sex chromosome exhibit quantitative parity ...
Xingcheng Xie, Yakun Zhang, Heyuan Peng, Zhongyuan Deng   +3 more
doaj   +1 more source

TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

Genetics in Medicine, 2019
Jiaqi Liu, N. Wu, Nan Yang, K. Takeda, Weisheng Chen, Weiyu Li, Renqian Du, Sen Liu, Yangzhong Zhou, Ling Zhang, Zhenlei Liu, Yuzhi Zuo, Sen Zhao, R. Blank, D. Pehlivan, Shuangshuang Dong, Jianguo Zhang, Jianxiong Shen, Nuo Si, Yi‐peng Wang, Gang Liu, Shugang Li, Yanxue Zhao, Hong Zhao, Yi-Xin Chen, Yu Zhao, Xiaofei Song, Jianhua Hu, Mao Lin, Ye Tian, Bo Yuan, K. Yu, Y. Niu, Bin Yu, Xiaoxin Li, Jia Chen, Zihui Yan, Qian-kun Zhu, Xiaolu Meng, Xiaoli Chen, Jianzhong Su, Xiuli Zhao, Xiaoyue Wang, Y. Ming, Xiao Li, C. Raggio, Baozhong Zhang, X. Weng, Shuyang Zhang, Xue Zhang, Kota Watanabe, M. Matsumoto, Li Jin, Yiping Shen, Nara Sobreira, J. Posey, P. Giampietro, D. Valle, Pengfei Liu, Zhihong Wu, S. Ikegawa, J. Lupski, Feng Zhang, G. Qiu, D. D. D. Study, Japan Early Onset Scoliosis Research Group, Baylor-Hopkins Center for Mendelian Genomics   +66 more
semanticscholar   +1 more source

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

FEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski, Irene Cortijo, Shruti Bhargava, Bernard Jover, Fabrice Raynaud, Juliana H Boukhaled, Anne‐Dominique Lajoix, Vera Jankowski, Joachim Jankowski, Magali Cordaillat‐Simmons, Àngel Argilés, Nathalie Gayrard, Flore Duranton, Jonas Laget   +13 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Utility of a C‐Jun Microsatellite Marker in Determining Gene Dosage for fatty (fa) [PDF]

, 1993
Streamson C. Chua, Moritz Hansen, Gary E. Truet, Rudolph L. Leibel   +3 more
openalex   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

The effect of Dnaaf5 gene dosage on primary ciliary dyskinesia phenotypes. [PDF]

JCI Insight, 2023
Horani A, Gupta DK, Xu J, Xu H, Carmen Puga-Molina LD, Santi CM, Ramagiri S, Brennan SK, Pan J, Koenitzer JR, Huang T, Hyland RM, Gunsten SP, Tzeng SC, Strahle JM, Mill P, Mahjoub MR, Dutcher SK, Brody SL.   +18 more
europepmc   +1 more source

Identification and characterization of a new Escherichia coli gene that is a dosage-dependent suppressor of a dnaK deletion mutation [PDF]

, 1990
Pil Jung Kang, Elizabeth A. Craig
openalex   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source