Results 211 to 220 of about 408,305 (347)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome. [PDF]

Adv Sci (Weinh)
He W, Luo Q, Zhao J, Wang M, Zhao A, Feng L, Reda A, Lindgren E, Stukenborg JB, Chen J, Deng Q.   +10 more
europepmc   +1 more source

Gene dosage and gene expression in the HLA region: Evidence from deletion variants

, 1982
P Gladstone, Lucy Fueresz, Donald Pious
openalex   +2 more sources

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Gene dosage of <i>PDR16</i> modulates azole susceptibility in <i>Candida auris</i>. [PDF]

Microbiol Spectr
Phan-Canh T, Bitencourt T, Kuchler K.
europepmc   +1 more source

Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice. [PDF]

Front Mol Neurosci, 2022
Yoo T, Yoo YE, Kang H, Kim E.
europepmc   +1 more source

IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice [PDF]

, 2015
Andrés J. López‐Contreras, Julia Specks, Jacqueline H. Barlow, Chiara Ambrogio, Claus Desler, Svante Vikingsson, Sara Rodrigo-Perez, Henrik Gréen, Lene Juel Rasmussen, Matilde Murga, André Nussenzweig, Óscar Fernández-Capetillo   +11 more
openalex   +1 more source

Reduced Gene Dosage of the Psychiatric Risk Gene <i>Cacna1c</i> Is Associated with Impairments in Hypothalamic-Pituitary-Adrenal Axis Activity in Rats. [PDF]

Int J Mol Sci
Moon AL, Mawson ER, Gasalla P, Wilkinson LS, Dwyer DM, Hall J, Thomas KL.   +6 more
europepmc   +1 more source

Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function. [PDF]

FASEB J, 2022
Seth A, Rivera A, Chahdi A, Choi IS, Medina-Martinez O, Lewis S, O'Neill M, Ridgeway A, Moore J, Jorgez C, Lamb DJ.   +10 more
europepmc   +1 more source