Results 221 to 230 of about 408,305 (347)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Increased gene dosage and mRNA expression from chromosomal duplications in Caenorhabditis elegans. [PDF]

G3 (Bethesda), 2022
Ragipani B, Albritton SE, Morao AK, Mesquita D, Kramer M, Ercan S.   +5 more
europepmc   +1 more source

The role of histone modifications and transposable elements in the epigenetic regulation of gene dosage after gene duplication [PDF]

Thomas Wolfe, Frédéric J. J. Chain
openalex   +1 more source

Sex-chromosome dosage effects on gene expression in humans [PDF]

, 2018
Armin Raznahan, Neelroop Parikshak, V. Ravi Chandran, Jonathan D. Blumenthal, Liv Clasen, Aaron Alexander‐Bloch, Andrew R. Zinn, Danny Wangsa, Jasen Wise, Declan Murphy, Patrick Bolton, Thomas Ried, Judith L. Ross, Jay N. Giedd, Daniel H. Geschwind   +14 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

DNA Methylation of <i>Igf2r</i> Promoter CpG Island 2 Governs <i>Cis</i>-Acting Inheritance and Gene Dosage in Equine Hybrids. [PDF]

Biology (Basel)
Wang X, Shen Y, Ren H, Yi M, Bou G.
europepmc   +1 more source

Gene-dosage effect of Pfkfb3 on monocyte/macrophage biology in atherosclerosis. [PDF]

Br J Pharmacol, 2022
Guo S, Li A, Fu X, Li Z, Cao K, Song M, Huang S, Li Z, Yan J, Wang L, Dai X, Feng D, Wang Y, He J, Huo Y, Xu Y.   +15 more
europepmc   +1 more source

Transient protein-protein interactions perturb E. coli metabolome and cause gene dosage toxicity

, 2016
Sanchari Bhattacharyya, Shimon Bershtein, Jin Yan, Tijda Argun, Amy I. Gilson, Sunia A. Trauger, Eugene I. Shakhnovich   +6 more
openalex   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Correction: Increased gene dosage of RFWD2 causes autistic-like behaviors and aberrant synaptic formation and function in mice. [PDF]

Mol Psychiatry
Li YX, Tan ZN, Li XH, Ma B, Adu Nti F, Lv XQ, Tian ZJ, Yan R, Man HY, Ma XM.   +9 more
europepmc   +1 more source