Results 251 to 260 of about 252,745 (293)

Gene dosage imbalances: action, reaction, and models

Trends in Biochemical Sciences, 2015
Single-gene deletions, duplications, and misregulation, as well as aneuploidy, can lead to stoichiometric imbalances within macromolecular complexes and cellular networks, causing their malfunction. Such alterations can be responsible for inherited or somatic genetic disorders including Mendelian diseases, aneuploid syndromes, and cancer. We review the
Veitia, Reiner A, Potier, Marie Claude
openaire   +4 more sources

Dosage-Dependent Gene Regulation in Multicellular Eukaryotes: Implications for Dosage Compensation, Aneuploid Syndromes, and Quantitative Traits

Developmental Biology, 2001
Evidence from a variety of data suggests that regulatory mechanisms in multicellular eukaryotes have evolved in such a manner that the stoichiometric relationship of the components of regulatory complexes affects target gene expression.
James A Birchler, Utpal Bhadra, Manika Pal Bhadra   +2 more
exaly   +2 more sources

Light regulates the gene expression of ribulosebisphosphate carboxylase at the levels of transcription and gene dosage in greening pea leaves

FEBS Letters, 1984
Ribulosebisphosphate carboxylase, composed of large and small subunits, is induced by light in pea leaves. During induction, the synthesis rate of the two mRNAs and the gene dosage were measured.
Yukiko Sasaki, Tadashi Kamikubo
exaly   +2 more sources

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Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation

Trends in Genetics, 2013
High-throughput genomic analyses have shown that many mutations, including loss-of-function (LOF) mutations, are present in diseased as well as in healthy individuals. Gene dosage effects due to deletions, duplications, and LOF mutations provide avenues to explore oligo- and multigenic inheritance. Here, we focus on several mechanisms that mediate gene
Reiner A, Veitia, Samuel, Bottani, James A, Birchler   +2 more
openaire   +2 more sources

Gene dosage and pathogenesis of Parkinson's disease

Trends in Molecular Medicine, 2005
Four recent papers related specifically to the familial form of Parkinson's disease reinforce the idea that endogenous levels of alpha-synuclein can strongly influence disease phenotype. Two recent publications of alpha-synuclein-duplication mutations show that the severity of familial Parkinsonian phenotype is dependent upon SNCA gene dosage and ...
Jason L, Eriksen, Serge, Przedborski, Leonard, Petrucelli   +2 more
openaire   +2 more sources

Regulation of MAL gene expression in yeast: Gene dosage effects

Molecular and General Genetics MGG, 1987
Both the MAL1 and MAL6 loci in Saccharomyces strains have been shown by functional and structural studies to comprise a cluster of at least three genes necessary for maltose utilization. They include regulatory, maltose transport and maltase genes designated MALR, MALT and MALS, respectively.
Goldenthal, M, VANONI, MARCO ERCOLE, Buchferer, B, Marmur, J.   +3 more
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Gene Dosage Compensation in Drosophila Melanogaster

1987
The comparative lack of sexual dimorphism of apricot and other [sex-linked] genes studied is due to "sex-limitation", i.e., to a compensatory influence of the dosage difference between the sexes in respect to other genes in the X-chromosome. The facts are of particular interest from an evolutionary standpoint.
J C, Lucchesi, J E, Manning
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Gene modulation in Drosophila: Dosage compensation and relocated v + genes

Biochemical Genetics, 1971
The v + gene of Drosophila and its associated enzyme, tryptophan pyrrolase, were employed in a study of the relationship between dosage compensation and the location of the gene in the genome. Enzyme assays performed on various genotypes indicate that although differently positioned genes may specify different enzyme activities, they still show dosage ...
J, Tobler, J T, Bowman, J R, Simmons
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The Gene Balance Hypothesis: Dosage Effects in Plants

2014
The concept of genomic balance traces to the early days of genetics. In recent years, studies of gene expression have found parallels to the classical phenotypic studies in that aneuploid changes have greater effects than whole genome changes. This has an explanation in terms of potential stoichiometric imbalances of the gene products encoded in the ...
Birchler, James A, Veitia, Reiner A
openaire   +3 more sources

Gene modulation in Drosophila: Dosage compensation of Pgd + and Zw + genes

Biochemical Genetics, 1973
The sex-linked Pgd+ and Zw+ genes of Drosophila melanogaster and their associated enzyme activities 6-phosphogluconate dehydrogenase and glucose 6-phosphate dehydrogenase were employed in an analysis of the relationship between dosage compensation and the location of genes in the genome.
J T, Bowman, J R, Simmons
openaire   +2 more sources