Results 11 to 20 of about 1,025,168 (353)
Systemic delivery of AAVrh74.tMCK.hCAPN3 rescues the phenotype in a mouse model for LGMD2A/R1
Molecular Therapy: Methods & Clinical Development, 2021 Limb girdle muscular dystrophy (LGMD) 2A/R1, caused by mutations in the CAPN3 gene and CAPN3 loss of function, is known to play a role in disease pathogenicity.
Zarife Sahenk +8 more
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Gene drives gaining speed [PDF]
Nature Reviews Genetics, 2021 Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR-Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species.
openaire +4 more sources
Frontiers in Bioengineering and Biotechnology, 2023 Gene drive-modified mosquitoes (GDMMs) are proposed as new tools for control and elimination of malaria and other mosquito-borne diseases, and promising results have been observed from testing conducted in containment. Although still at an early stage of
Stephanie L. James +3 more
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Expanding the CRISPR toolbox in Culicine mosquitoes: in vitro validation of Pol III promoters [PDF]
, 2020 CRISPR–Cas9-based “gene drive” technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date—and an expanded molecular toolbox with which
Alphey, Luke +6 more
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Applied Biosafety, 2017 Biosafety risk assessment and containment framework strategies for research involving gene drives pose a challenge, as there are no published guidelines or regulatory information yet written specif...
Partha Krishnan, David Gillum
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Selfing is the safest sex for Caenorhabditis tropicalis
eLife, 2021 Mating systems have profound effects on genetic diversity and compatibility. The convergent evolution of self-fertilization in three Caenorhabditis species provides a powerful lens to examine causes and consequences of mating system transitions.
Luke M Noble +13 more
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Anopheles gambiae Genome Conservation as a Resource for Rational Gene Drive Target Site Selection
Insects, 2021 The increase in molecular tools for the genetic engineering of insect pests and disease vectors, such as Anopheles mosquitoes that transmit malaria, has led to an unprecedented investigation of the genomic landscape of these organisms.
Nace Kranjc +3 more
doaj +1 more source
Science, 2014 Regulatory gaps must be filled before gene drives could be used in the ...
Kenneth A. Oye +9 more
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Evading resistance to gene drives [PDF]
Genetics, 2020 Abstract Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gene drives are prone to select resistance, should it arise. Here, we develop mathematical
Richard Gomulkiewicz +2 more
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Journal of Responsible Innovation, 2017 When scientists alter the genome of an organism, we typically reduce its ability to reproduce in the wild.
John Min +3 more
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