Results 11 to 20 of about 1,021,897 (307)
Driving down malaria transmission with engineered gene drives
Frontiers in Genetics, 2022 The last century has witnessed the introduction, establishment and expansion of mosquito-borne diseases into diverse new geographic ranges. Malaria is transmitted by female Anopheles mosquitoes.
William T. Garrood +5 more
doaj +5 more sources
Making gene drive biodegradable [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Gene drive systems have long been sought to modify mosquito populations and thus combat malaria and dengue. Powerful gene drive systems have been developed in laboratory experiments, but may never be used in practice unless they can be shown to be acceptable through rigorous field-based testing. Such testing is complicated by the anticipated difficulty
Josef Zapletal +5 more
openaire +2 more sources
Gene drives gaining speed [PDF]
Nature Reviews Genetics, 2021 Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian (>50%) frequencies. Recently developed CRISPR-Cas9-based gene-drive systems are highly efficient in laboratory settings, offering the potential to reduce the prevalence of vector-borne diseases, crop pests and non-native invasive species.
openaire +4 more sources
Gene Drive: Evolved and Synthetic [PDF]
ACS Chemical Biology, 2018 Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing ...
Burt, Austin, Crisanti, Andrea
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Applied Biosafety, 2017 Biosafety risk assessment and containment framework strategies for research involving gene drives pose a challenge, as there are no published guidelines or regulatory information yet written specif...
Partha Krishnan, David Gillum
openaire +1 more source
Science, 2014 Regulatory gaps must be filled before gene drives could be used in the ...
Kenneth A. Oye +9 more
openaire +1 more source
Evading resistance to gene drives [PDF]
Genetics, 2020 Abstract Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gene drives are prone to select resistance, should it arise. Here, we develop mathematical
Richard Gomulkiewicz +2 more
openaire +2 more sources
Journal of Responsible Innovation, 2017 When scientists alter the genome of an organism, we typically reduce its ability to reproduce in the wild.
John Min +3 more
openaire +2 more sources
Molecular Therapy: Methods & Clinical Development, 2019 rAAVrh74.MCK.GALGT2 is a surrogate gene therapy that inhibits muscular dystrophy in multiple animal models. Here, we report on a dose-response study of functional muscle GALGT2 expression as well as toxicity and biodistribution studies after systemic ...
Deborah A. Zygmunt +10 more
doaj +1 more source
Analysis of a conserved cellulase transcriptional regulator reveals inducer-independent production of cellulolytic enzymes in Neurospora crassa. [PDF]
, 2013 Cellulose is recalcitrant to deconstruction to glucose for use in fermentation strategies for biofuels and chemicals derived from lignocellulose. In Neurospora crassa, the transcriptional regulator, CLR-2, is required for cellulolytic gene expression and
Coradetti, Samuel +2 more
core +2 more sources