Transforming malaria prevention and control: the prospects and challenges of gene drive technology for mosquito management [PDF]
Annals of Medicine, 2023 Background: In the era of insecticides and anti-malarial drug resistance, gene drive technology holds considerable promise for malaria control. Gene drive technology deploys genetic modifications into mosquito populations to impede their ability to ...
Yusuf Amuda Tajudeen +7 more
doaj +5 more sources
Gene drives as a new quality in GMO releases—a comparative technology characterization [PDF]
PeerJ, 2019 Compared to previous releases of genetically modified organisms (GMOs) which were primarily plants, gene drives represent a paradigm shift in the handling of GMOs: Current regulation of the release of GMOs assumes that for specific periods of time a ...
Johannes L. Frieß +2 more
doaj +5 more sources
Governing Gene Drive Technologies: A Qualitative Interview Study [PDF]
AJOB Empirical Bioethics, 2021 Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such as vector-borne diseases. A key issue in the debate on GDTs relates to what governance is appropriate for these
Nienke de Graeff +3 more
openalex +5 more sources
Developing gene drive technologies to eradicate invasive rodents from islands [PDF]
Journal of Responsible Innovation, 2017 Island ecosystems are highly threatened by invasive rats and mice. Currently, the only effective technology for eradicating rodents from islands is toxicants.
Caroline M. Leitschuh +7 more
openalex +2 more sources
General science‐technology orientation, specific benefit–risk assessment frame, and public acceptance of gene drive biotechnology [PDF]
Risk Analysis, 2023 AbstractWith limited understanding of most new biotechnologies, how do citizens form their opinion and what factors influence their attitudes about these innovations? In this study, we use gene drive biotechnology in agricultural pest management as an example and theoretically propose that given low levels of knowledge and awareness, citizens ...
Xinsheng Liu +7 more
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Gene drives in our future: challenges of and opportunities for using a self-sustaining technology in pest and vector management [PDF]
BMC Proceedings, 2018 Gene drives are systems of biased inheritance that enhance the likelihood a sequence of DNA passes between generations through sexual reproduction and potentially throughout a local population and ultimately all connected populations of a species.
James P. Collins
doaj +2 more sources
Experts’ moral views on gene drive technologies: a qualitative interview study [PDF]
BMC Medical Ethics, 2021 Abstract Background Gene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests.
Nienke de Graeff +2 more
openalex +6 more sources
A Framework for the Risk Assessment and Management of Gene Drive Technology in Contained Use [PDF]
Applied Biosafety, 2018 The utilisation of the CRISPR/Cas9 technology has sparked a renewed interest in gene drive mechanisms.
Cécile J.B. van der Vlugt +4 more
openalex +4 more sources
Steps Towards a Precautionary Risk Governance of SPAGE Technologies Including Gene-Drives [PDF]
, 2020 In view of the rapid dynamics of genetic engineering development (in particular regarding the ‘new gene-technologies’ gene editing, self-propagating artificial genetic elements (SPAGE) and synthetic biology), the question is being intensively discussed whether the currently practiced risk governance is sufficient to guarantee the desired high level of ...
Arnim von Gleich
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Nuclease-based gene drives, an innovative tool for insect vector control: advantages and challenges of the technology [PDF]
Current Opinion in Insect Science, 2020 Genetic control of insects involves the release of modified insects that contain altered genetic traits and are competent to mate with target populations to introduce the traits therein. Since it relies on mating, this type of control is species-specific, non-toxic, and has the advantage that the released insects can do the difficult task of reaching ...
Charlotte M Quinn, Tony Nolan
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