Results 31 to 40 of about 189,147 (282)

Designing gene drives to limit spillover to non-target populations.

PLoS Genetics, 2021
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations has generated much excitement. However, the potential for spillovers of gene-drive alleles from the target population to non-target populations has raised concerns ...
Gili Greenbaum, Marcus W Feldman, Noah A Rosenberg, Jaehee Kim   +3 more
doaj   +1 more source

California Residents’ Perceptions of Gene Drive Systems to Control Mosquito-Borne Disease

Frontiers in Bioengineering and Biotechnology, 2022
Scientists developing gene drive mosquitoes for vector control must understand how residents of affected areas regard both the problem of mosquito-borne disease and the potential solutions offered by gene drive.
Cynthia E. Schairer, Cynthia Triplett, Cynthia Triplett, Omar S. Akbari, Cinnamon S. Bloss, Cinnamon S. Bloss, Cinnamon S. Bloss   +6 more
doaj   +1 more source

Reflection on the Challenges, Accomplishments, and New Frontiers of Gene Drives

BioDesign Research, 2022
Ongoing pest and disease outbreaks pose a serious threat to human, crop, and animal lives, emphasizing the need for constant genetic discoveries that could serve as mitigation strategies.
Michael Melesse Vergara, Jesse Labbé, Joanna Tannous   +2 more
doaj   +1 more source

Problem formulation for gene drive mosquitoes designed to reduce malaria transmission in Africa: results from four regional consultations 2016–2018

Malaria Journal, 2019
Background Gene drive mosquitoes have been proposed as a possible means to reduce the transmission of malaria in Africa. Because this technology has no prior use-history at this time, environmental risk assessments for gene drive mosquitoes will benefit ...
John L. Teem, Aggrey Ambali, Barbara Glover, Jeremy Ouedraogo, Diran Makinde, Andrew Roberts   +5 more
doaj   +1 more source

Small-scale release of non-gene drive mosquitoes in Burkina Faso: from engagement implementation to assessment, a learning journey

Malaria Journal, 2021
Background Innovative tools are needed to complement the existing approach for malaria elimination. Gene drive mosquitoes are one potential new technology in the control of malaria vectors.
Lea Pare Toe, Nourou Barry, Anselme D. Ky, Souleymane Kekele, Wilfrid Meda, Korotimi Bayala, Mouhamed Drabo, Delphine Thizy, Abdoulaye Diabate   +8 more
doaj   +1 more source

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes

Nature Communications, 2020
Genetic variation in natural populations could represent gene drive resistant alleles, preventing successful application for population management. Here the authors survey 1280 genomes from three mosquito species and concludes natural variation will not ...
Hanno Schmidt, Travis C. Collier, Mark J. Hanemaaijer, Parker D. Houston, Yoosook Lee, Gregory C. Lanzaro   +5 more
doaj   +1 more source

Ugandan stakeholder hopes and concerns about gene drive mosquitoes for malaria control: new directions for gene drive risk governance

Malaria Journal, 2021
Background The African Union’s High-Level Panel on Emerging Technologies identified gene drive mosquitoes as a priority technology for malaria elimination. The first field trials are expected in 5–10 years in Uganda, Mali or Burkina Faso. In preparation,
Sarah Hartley, Robert D. J. Smith, Adam Kokotovich, Chris Opesen, Tibebu Habtewold, Katie Ledingham, Ben Raymond, Charles B. Rwabukwali   +7 more
doaj   +1 more source

Assessment of distant-site rescue elements for CRISPR toxin-antidote gene drives

Frontiers in Bioengineering and Biotechnology, 2023
Gene drive is a genetic engineering technology that can enable super-mendelian inheritance of specific alleles, allowing them to spread through a population.
Jingheng Chen, Xuejiao Xu, Jackson Champer   +2 more
doaj   +1 more source

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito. [PDF]

PLoS Genetics, 2017
Gene drives have enormous potential for the control of insect populations of medical and agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly introduce genetic traits even if these confer a negative fitness ...
Andrew M Hammond, Kyros Kyrou, Marco Bruttini, Ace North, Roberto Galizi, Xenia Karlsson, Nace Kranjc, Francesco M Carpi, Romina D'Aurizio, Andrea Crisanti, Tony Nolan   +10 more
doaj   +1 more source

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research [version 1; peer review: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2020
The progress in gene drive research has made the possibility of a future release in the environment probable. This prospect is raising new questions related to the adequacy of the policy frameworks in place to manage and regulate the research and its ...
Delphine Thizy, Isabelle Coche, Jantina de Vries   +2 more
doaj   +1 more source