Results 101 to 110 of about 6,833,475 (368)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Hierarchy and Feedback in the Evolution of the E. coli Transcription Network [PDF]
, 2007 The E.coli transcription network has an essentially feedforward structure, with, however, abundant feedback at the level of self-regulations. Here, we investigate how these properties emerged during evolution.
Atkinson +28 more
core +2 more sources
GENE DUPLICATION AND PHYLOGENY IN CLARKIA [PDF]
Evolution, 1979 Direct evidence for the descent of a group of species from a single common ancestor is rarely possible in the absence of fossils. Consequently, phylogenetic taxonomy relies on comparative analysis of morphological, chromosomal, and biochemical characters for evidence of relationship.
N. F. Weeden, Leslie D. Gottlieb
openaire +3 more sources
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
The root of the universal tree and the origin of eukaryotes based on elongation factor phylogeny [PDF]
, 1996 The genes for the protein synthesis elongation factors Tu (EF-Tu) and G (EF-G) are the products of an ancient gene duplication, which appears to predate the divergence of all extant organismal lineages.
Baldauf, S.L. +2 more
core +2 more sources
Genomic evidence for adaptation by gene duplication
Genome Research, 2014 Gene duplication is widely believed to facilitate adaptation, but unambiguous evidence for this hypothesis has been found in only a small number of cases.
Wenfeng Qian, Jianzhi Zhang
semanticscholar +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
The divergence of alternative splicing between ohnologs in teleost fishes
BMC Ecology and Evolution, 2021 Background Gene duplication and alternative splicing (AS) are two distinct mechanisms generating new materials for genetic innovations. The evolutionary link between gene duplication and AS is still controversial, due to utilizing duplicates from ...
Yuwei Wang, Baocheng Guo
doaj +1 more source
TBK1 gene duplication and normal-tension glaucoma.
JAMA ophthalmology, 2014 IMPORTANCE Normal-tension glaucoma (NTG) is a common cause of vision loss. OBJECTIVE To investigate the role of TANK binding kinase 1 (TBK1) gene duplications in NTG to gain insights into the causes of glaucoma that occurs at low intraocular pressure ...
R. Ritch +11 more
semanticscholar +1 more source
Gene Duplication and Ectopic Gene Conversion in Drosophila [PDF]
Genes, 2011 The evolutionary impact of gene duplication events has been a theme of Drosophila genetics dating back to the Morgan School. While considerable attention has been placed on the genetic novelties that duplicates are capable of introducing, and the role that positive selection plays in their early stages of duplicate evolution, much less attention has ...
J. Roman Arguello, Tim Connallon
openaire +3 more sources