Results 101 to 110 of about 318,177 (248)
The evolution of microRNA-regulation in duplicated genes facilitates expression divergence [PDF]
arXiv, 2008 Background: The evolution of microRNA regulation in metazoans is a mysterious process: MicroRNA sequences are highly conserved among distal organisms, but on the other hand, there is no evident conservation of their targets. Results: We study this extensive rewiring of the microRNA regulatory network by analyzing the evolutionary trajectories of ...
arxiv
Evolutionary and topological properties of gene modules and driver mutations in a leukemia gene regulatory network [PDF]
, 2015 The diverse, specialized genes in today's lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a complex network of interactions, and alterations in one gene may drive reciprocal changes in its proteins' binding partners.
arxiv +1 more source
The (In)dependence of Alternative Splicing and Gene Duplication
PLoS Computational Biology, 2007 Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples have shown that sequence changes introduced by AS may be comparable to those introduced by GD. In addition, the two processes are inversely correlated at the genomic scale: large gene families are depleted in splice variants and
Xavier de la Cruz +5 more
openaire +7 more sources
Molecular Plant-Microbe Interactions, 2005 Arabidopsis thaliana is believed to have experienced at least two and possibly three whole-genome duplication events in its evolutionary history. In order to investigate the evolutionary relationships between these duplication events and diversification ...
Kan Nobuta +3 more
doaj +1 more source
Content based network model with duplication and divergence
, 2005 We construct a minimal content-based realization of the duplication and divergence model of genomic networks introduced by Wagner [A. Wagner, Proc. Natl. Acad. Sci.
Albert +34 more
core +1 more source
Gene duplication and inactivation in the HPRT gene family
Genomics, 2007 Hypoxanthine phosphoribosyltransferase (HPRT1) is a key enzyme in the purine salvage pathway, and mutations in HPRT1 cause Lesch-Nyhan disease. The studies described here utilized targeted comparative mapping and sequencing, in conjunction with database searches, to assemble a collection of 53 HPRT1 homologs from 28 vertebrates.
James W. Thomas +3 more
openaire +2 more sources
Rapid Bursts of \u3ci\u3eAndrogen-Binding Protein (Abp)\u3c/i\u3e Gene Duplication Occurred Independently in Diverse Mammals [PDF]
, 2008 Background The draft mouse (Mus musculus) genome sequence revealed an unexpected proliferation of gene duplicates encoding a family of secretoglobin proteins including the androgen-binding protein (ABP) α, β and γ subunits.
Blakely, Tyler D. +5 more
core +1 more source
A 3-approximation algorithm for computing a parsimonious first speciation in the gene duplication model [PDF]
arXiv, 2009 We consider the following problem: from a given set of gene families trees on a set of genomes, find a first speciation, that splits these genomes into two subsets, that minimizes the number of gene duplications that happened before this speciation. We call this problem the Minimum Duplication Bipartition Problem.
arxiv
Progressive Mauve: Multiple alignment of genomes with gene flux and rearrangement [PDF]
, 2009 Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.
Darling, Aaron E. +2 more
core
Special Issue: Gene Conversion in Duplicated Genes [PDF]
Genes, 2011 Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the
openaire +3 more sources