Rapid loss of duplicate gene expression by natural selection [PDF]
, 1979 Fred W. Allendorf
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Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald +74 more
wiley +1 more source
An ILP solution for the gene duplication problem
BMC Bioinformatics, 2011 Background The gene duplication (GD) problem seeks a species tree that implies the fewest gene duplication events across a given collection of gene trees.
Fernández-Baca David F +3 more
doaj +1 more source
Phosphorylation network rewiring by gene duplication
Molecular Systems Biology, 2011 Elucidating how complex regulatory networks have assembled during evolution requires a detailed understanding of the evolutionary dynamics that follow gene duplication events, including changes in post‐translational modifications.
Luca Freschi +4 more
doaj +1 more source
The Mechanism of Expansion and the Volatility it created in Three Pheromone Gene Clusters in the Mouse (\u3ci\u3eMus musculus\u3c/i\u3e) Genome [PDF]
, 2009 Three families of proteinaceous pheromones have been described in the house mouse: androgen-binding proteins (ABPs), exocrine gland–secreting peptides (ESPs), and major urinary proteins (MUPs), each of which is thought to communicate different ...
Karn, Robert C., Laukaitis, Christina M.
core +1 more source
Practice Recommendations for Genetic Testing of Ataxias
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan +7 more
wiley +1 more source
Duplications of histidine transport genes in Salmonella typhimurium and their use for the selection of deletion mutants [PDF]
, 1978 G F Ames, D. Biek, Elena N. Spudich
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Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan +12 more
wiley +1 more source
On the Evidence for Partial Gene Duplication from Amino Acid Sequence of Bovine Glutamate Dehydrogenase (reply) [PDF]
, 1974 Paul C. Engel
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Plasma p‐tau181 has proven to be a promising diagnostic and prognostic tool in the earliest phases of Alzheimer's disease (AD). We aimed to evaluate the prognostic role of p‐tau181 in predicting conversion to AD dementia and worsening in cognition in mild cognitive impairment (MCI) and subjective cognitive decline (SCD).
Giulia Giacomucci +12 more
wiley +1 more source