Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery
Advanced Functional Materials, EarlyView.This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer +10 more
wiley +1 more source
INFLUENCE OF GENE DUPLICATION AND X-INACTIVATION ON MOUSE MITOCHONDRIAL MALIC ENZYME ACTIVITY AND ELECTROPHORETIC PATTERNS [PDF]
, 1977 Eva M. Eicher, Douglas L. Coleman
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Advanced Functional Materials, EarlyView.This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras +19 more
wiley +1 more source
Duplications of histidine transport genes in Salmonella typhimurium and their use for the selection of deletion mutants [PDF]
, 1978 G F Ames, D. Biek, Elena N. Spudich
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The Hierarchical Structure of Sheep Wool and Its Impact on Physical Properties
Advanced Functional Materials, EarlyView.Sheep wool, a prevalent α‐keratinous fiber, is an essential model for studying protein‐based fibers. Its genetic diversity across breeds enables the establishment of multiscale structure‐property relationships, uncovering previously elusive insights into wool's hierarchical structure.
Serafina R. France Tribe +9 more
wiley +1 more source
GENE DUPLICATION WITHIN THE FAMILY SALMONIDAE: DISOMIC INHERITANCE OF TWO LOCI REPORTED TO BE TETRASOMIC IN RAINBOW TROUT [PDF]
, 1973 Frederick W. Allendorf, Fred M. Utter
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Advanced Healthcare Materials, EarlyView.Reihs et al. present the development of a humanized, animal‐free synovial membrane model for osteoarthritis. Methods include 3D biochip cultures of human‐primary OA synoviocytes with matrix and serum surrogates. Results show replication of synovial architecture and increased Yap1 expression.
Eva I. Reihs +17 more
wiley +1 more source
Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo
Advanced Healthcare Materials, EarlyView.This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla +16 more
wiley +1 more source
Multiple gene duplication in the evolution of plasminogen. Five regions of sequence homology with the two internally homologous structures in prothrombin [PDF]
, 1976 H. Claeys +4 more
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