Results 221 to 230 of about 6,833,475 (368)

Gene Duplication in a Patient With Usher Syndrome Type 2C: A Case Report. [PDF]

Cureus
Ruiz Matos SJ, Negrón Lugo KA, Izquierdo N.   +2 more
europepmc   +1 more source

ALCOHOL DEHYDROGENASE IN THE DIPLOID PLANT STEPHANOMERIA EXIGUA (COMPOSITAE): GENE DUPLICATION, MODE OF INHERITANCE AND LINKAGE [PDF]

, 1980
Mikeal L. Roose, L. D. Gottlieb
openalex   +1 more source

The Nuclear Localization of ACLY Guards Early Embryo Development Through Recruiting P300 and HAT1 to Promote Histone Acetylation and Transcription

Advanced Science, EarlyView.
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma, Yingyi Zhang, Weijie Yang, Xiaomei Tong, Siya Liu, Yan Zhou, Mengjia Qiu, Huifang Jiang, Zhanhong Hu, Peipei Ren, Yan Rong, Mengru Lai, Jiamin Jin, Fei Huang, Liujian Ouyang, Feng Zhou, Heng‐Yu Fan, Yin‐Li Zhang, Songying Zhang   +18 more
wiley   +1 more source

ERCnet: Phylogenomic Prediction of Interaction Networks in the Presence of Gene Duplication. [PDF]

Mol Biol Evol
Forsythe ES, Gatts TC, Lane LE, deRoux C, Berggren MJ, Rehmann EA, Zak EN, Bartel T, L'Argent LA, Sloan DB.   +9 more
europepmc   +1 more source

cDNA sequence encoding the 16-kDa proteolipid of chromaffin granules implies gene duplication in the evolution of H+-ATPases.

, 1988
M. Mandel, Yoshinori Moriyama, J D Hulmes, Y C Pan, Hannah Nelson, Nathan Nelson   +5 more
openalex   +1 more source

The Non‐Coding Regulatory Variant rs2863002 at chr11p11.2 Increases Neuroblastoma Risk by Affecting HSD17B12 Expression and Lipid Metabolism

Advanced Science, EarlyView.
The SNP rs2863002 at the 11p11.2 locus, identified through GWAS, is associated with an increased risk of neuroblastoma. The rs2863002‐C allele impairs the binding of the transcription factor GATA3, resulting in upregulation of the HSD17B12 gene.
Teresa Maiorino, Marianna Avitabile, Vincenzo Aievola, Annalaura Montella, Vito A. Lasorsa, Ferdinando Bonfiglio, Mariagrazia Cantalupo, Sueva Cantalupo, Gilda Estinto, Matilde Tirelli, Martina Morini, Martina Ardito, Alessandra Eva, Vincenza Cerbone, Lucia Mauriello, Marianna Caterino, Margherita Ruoppolo, John M. Maris, Sharon J. Diskin, Achille Iolascon, Mario Capasso   +20 more
wiley   +1 more source

Identification and Structural Characterization of a Novel COL3A1 Gene Duplication in a Family With Vascular Ehlers-Danlos Syndrome. [PDF]

Mol Genet Genomic Med
Miolo G, Machin P, De Conto M, Fortuna S, Viglio S, Della Puppa L, Geremia S, Corona G.   +7 more
europepmc   +1 more source

Toxoplasma ceramide synthases: Gene duplication, functional divergence, and roles in parasite fitness. [PDF]

FASEB J, 2023
Koutsogiannis Z, Mina JG, Albus CA, Kol MA, Holthuis JCM, Pohl E, Denny PW.   +6 more
europepmc   +1 more source

Duplication of large genomic regions during the evolution of vertebrate homeobox genes.

, 1989
Klaus Schughart, Claudia Kappen, F.H. Ruddle   +2 more
openalex   +1 more source

Enhanced Activities of OCT4 and SOX2 Promote Epigenetic Reprogramming by Shortening G1 Phase

Advanced Science, EarlyView.
Fusing the VP16 domain to OCT4 and SOX2 (OvSvK) enhances iPSC generation by activating downstream targets, including those regulating the cell cycle. This accelerates reprogramming by shortening the G1 phase and reducing H3K27me3 levels. Modulating Ccnd1, Cdkn2a, and Ccne1 improves efficiency, linking cell cycle to epigenetic remodeling.
Lin Guo, Jiechun Lin, Qiwen Ren, Hao Sun, Yanhua Wu, Haofei Ge, Xiaolan Wu, Lihui Lin, Lining Liang, Changpeng Li, He Liu, Yuangbang Mai, Shilong Chu, Jiadong Liu, Jing Liu, Jiekai Chen, Duanqing Pei, Hui Zheng   +17 more
wiley   +1 more source