Results 251 to 260 of about 7,215,457 (388)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Mitochondrial Genome Analysis of <i>Isatis tinctoria</i> L. (Brassicaceae) Reveals Strengthened Purifying Selection Resulting From Recombination-Driven Gene Duplication. [PDF]

Ecol Evol
Li Y, Hao X, Bi Y, Zuo Y, Sun X.
europepmc   +1 more source

The Probability of Duplicate Gene Preservation by Subfunctionalization [PDF]

, 2000
Michael Lynch, Allan Force
openalex   +1 more source

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Evolutionary dynamics of Orchid DL paralogs: gene duplication, functional divergence, and expression patterns across Orchid subfamilies. [PDF]

BMC Plant Biol
Lucibelli F, Carfora A, Becker A, Ehlers K, Aceto S.   +4 more
europepmc   +1 more source

Pathogenic Yersinia Species Carry a Novel, Cold-Inducible Major Cold Shock Protein Tandem Gene Duplication Producing both Bicistronic and Monocistronic mRNA [PDF]

, 1999
Klaus Neuhaus, Kevin P. Francis, Sonja Rapposch, Angelika Görg, Siegfried Scherer   +4 more
openalex   +1 more source

HTGTS‐TCR‐Seq for Profiling of Mouse and Human T‐Cell Receptor α and β Gene Rearrangements and Diversity

Advanced Science, EarlyView.
HTGTS‐TCR‐seq is an efficient and cost‐effective method for profiling TCRα and TCRβ rearrangements using only a few primers. It captures both productive and nonproductive recombination events, minimizes primer bias, and reveals stage‐specific and age‐related repertoire changes in mice, as well as conserved features in human peripheral T cells ...
Rui Luo, Yawei Song, Meichen Wang, Longhao Zou, Fangtai Jiao, Tiange Yang, Guangchuan Wang, Zhuoyi Liang, Wei Wu, Hai‐Qiang Dai   +9 more
wiley   +1 more source

The adaptive value of recombination in resolving intralocus sexual conflict by gene duplication. [PDF]

Proc Biol Sci
Harper JA, Morrow EH.
europepmc   +1 more source

Analysis of the relationship between functional divergence and the propensity of duplicated genes to be involved in human Mendelian diseases

, 2017
Katherina Radan
openalex   +1 more source

A case report: Becker muscular dystrophy presenting with epilepsy and dysgnosia induced by duplication mutation of Dystrophin gene [PDF]

, 2016
Jing Miao, Jiachun Feng, Dan Zhu, Xuefan Yu   +3 more
openalex   +1 more source