Results 21 to 30 of about 3,440,639 (300)

The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana

BMC Plant Biology, 2004
Background Most genes in Arabidopsis thaliana are members of gene families. How do the members of gene families arise, and how are gene family copy numbers maintained?
Baumgarten Andrew, Mitra Arvind, Cannon Steven B, Young Nevin D, May Georgiana   +4 more
doaj   +1 more source

Horizontal transfer, not duplication, drives the expansion of protein families in prokaryotes. [PDF]

PLoS Genetics, 2011
Gene duplication followed by neo- or sub-functionalization deeply impacts the evolution of protein families and is regarded as the main source of adaptive functional novelty in eukaryotes.
Todd J Treangen, Eduardo P C Rocha
doaj   +1 more source

Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila [PDF]

, 2008
Background. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a complex gene.
Butlin, Roger K., Gardiner, Anastasia, Gardiner, A., Jordan, W.C., Ritchie Michael G., Ritchie, M.G., Jordan, William C., Michael G Ritchie, Barker, Daniel, William C Jordan, Barker, D., Ritchie, Michael G., Gardiner Anastasia, Daniel Barker, Anastasia Gardiner, Barker Daniel, Roger K Butlin, Jordan William C., Butlin, R.K., Butlin Roger K., Ritchie, Michael G.; id_orcid   +20 more
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Profiling of gene duplication patterns of sequenced teleost genomes: evidence for rapid lineage-specific genome expansion mediated by recent tandem duplications

BMC Genomics, 2012
Background Gene duplication has had a major impact on genome evolution. Localized (or tandem) duplication resulting from unequal crossing over and whole genome duplication are believed to be the two dominant mechanisms contributing to vertebrate genome ...
Lu Jianguo, Peatman Eric, Tang Haibao, Lewis Joshua, Liu Zhanjiang   +4 more
doaj   +1 more source

Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region [PDF]

, 2012
Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With the world-wide emergence of drug resistance, and the finding of more functional
Gagneux, Sebastian, Michael Koehrsen (185361), Bonnie B Plikaytis, van Helden, Paul D., Sisk, P., Stolte, Christian, Hung, D., Jared White, Paul D. van Helden (33594), Gey van Pittius, Nicolass C., Brian Weiner, Gagneux, Sebastien, Gomez James, Bruce Birren, Sisk, Peter, Hung, Deborah, Sloutsky Alexander, White, Jared, Robert M. Warren (185350), Nicolass C. Gey van Pittius (185359), Deborah Hung (185364), Birren, Bruce, Warren, Robert M., Peter Sisk (185362), Galagan, J., van Helden, P. D., Robert M Warren, Nicolass C Gey van Pittius, Bonnie B. Plikaytis (185356), Paul D van Helden, Megan Murray (63415), Birren Bruce, Plikaytis, Bonnie B., Weiner, Brian, Koehrsen Michael, Galagan, James E., Victor Thomas C., Warren, R. M., Sloutsky, A., Bruce Birren (18146), Weiner Brian, Birren, B., Van Pittius, Nicolaas C. Gey, Christian Stolte, Stolte Christian, Gomez, J., Posey James E., Plikaytis Bonnie B., Gagneux, S., Peter Sisk, Brian Weiner (164963), James Gomez (185343), Posey, J. E., Thomas C Victor, Michael Koehrsen, Jared White (185363), Galagan James, Weiner, B., James Gomez, Warren Robert M., Gagneux Sebastien, James Galagan (185365), Murray, M., White Jared, Gey van Pittius, N. C., Galagan, James, James E Posey, White, J., Sloutsky, Alexander, Hung Deborah, Alexander Sloutsky, Stolte, C., James Galagan, Gomez, James, Deborah Hung, Sebastien Gagneux (149824), Plikaytis, B. B., Posey, James E., Koehrsen, M., Warren, Rob, van Helden Paul D., Alexander Sloutsky (185354), Sisk Peter, Sebastien Gagneux, Murray Megan, James E. Posey (155073), Murray, Megan, Megan Murray, Koehrsen, Michael, Victor, Thomas C., Victor, T. C., Christian Stolte (2869), Gey van Pittius Nicolass C., Thomas C. Victor (185348)   +93 more
core   +2 more sources

Towards more biological mutation operators in gene regulation studies [PDF]

, 2003
Genetic regulation is often viewed as a complex system whose properties emerge from the interaction of regulatory genes. One major paradigm for studying the complex dynamics of gene regulation uses directed graphs to explore structure, behaviour and ...
Wiles, J., Nicholas Geard, Watson, J., Geard, N, Wiles, Janet, Watson, James, Janet Wiles, Wiles, J, Watson, J, James Watson, Geard, N.L., Geard, Nicholas   +11 more
core   +1 more source

The 46, XX Ovotesticular Disorder of Sex Development With Xq27.1q27.2 Duplication Involving the SOX3 Gene: A Rare Case Report and Literature Review

Frontiers in Pediatrics, 2021
Background: Very few reports are available on human XX ovotesticular disorder of sex development involving SOX3 gene duplication. Here we aim to present a rare case of SOX3 gene duplication in a person from the Chinese population who exhibits XX ...
Jianlong Zhuang, Chunnuan Chen, Jia Li, Yuying Jiang, Junyu Wang, Yuanbai Wang, Shuhong Zeng, Yiming Lin, Yingjun Xie, Yingjun Xie   +9 more
doaj   +1 more source

8p23.1 duplication syndrome differentiated from copy number variation of the defensin cluster at prenatal diagnosis in four new families [PDF]

, 2010
Background: the 8p23.1 duplication syndrome and copy number variation of the 8p23.1 defensin gene cluster are cytogenetically indistinguishable but distinct at the molecular level.
Emma-Jane Taylor, Liehr, Thomas, Susanne Morlot, Joana Trindade, Ocraft, Kevin, Ana I Paramos, Viv K Maloney, Paramos Ana I, Bunyan Dave, Curtis, Merryl, Claudia Alves, Merryl Curtis, Maloney, Viv K., Dermitzel Anette, Bunyan, Dave, Denise Robinson, Dermitzel, Anette, Thomas Liehr, Alves Claudia, John CK Barber, Kevin Ocraft, Taylor, Emma-Jane, Clare Cooper, Alves, Claudia, Taylor Emma-Jane, Anette Dermitzel, Curtis Merryl, Ocraft Kevin, Barber John CK, Cooper Clare, Paramos, Ana I., Cooper, Clare, Liehr Thomas, Barber, John C.K., Robinson, Denise, Trindade Joana, Morlot, Susanne, Morlot Susanne, Robinson Denise, Maloney Viv K, Dave Bunyan, Trindade, Joana   +41 more
core   +1 more source

Genome duplication and gene loss affect the evolution of heat shock transcription factor genes in legumes. [PDF]

PLoS ONE, 2014
Whole-genome duplication events (polyploidy events) and gene loss events have played important roles in the evolution of legumes. Here we show that the vast majority of Hsf gene duplications resulted from whole genome duplication events rather than ...
Yongxiang Lin, Ying Cheng, Jing Jin, Xiaolei Jin, Haiyang Jiang, Hanwei Yan, Beijiu Cheng   +6 more
doaj   +1 more source

Gene duplication and fragmentation in the zebra finch major histocompatibility complex [PDF]

, 2010
BACKGROUND: Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects.
Tina Graves, Griffin, D.K., Wesley C Warren, Edwards, Scott, Völker, Martin, Völker Martin, Westerdahl Helena, Burt, D.W., Graves, Tina, Griffin Darren K, Martin Völker, Burt, David W, Darren K Griffin, Helena Westerdahl, Godinez Ricardo, Edwards, S.V., Edwards, Scott V, Kotkiewicz, H., Ekblom, Robert,, Ekblom Robert, Warren, Wesley C, Warren, W.C., Ekblom, Robert, Robert Ekblom, David W Burt, Ricardo Godinez, Warren, Wesley C., Scott V Edwards, Lund University., Griffin, Darren K., Godinez, Ricardo, Westerdahl, Helena, Ekblom, R., Westerdahl, Helena,, Edwards, Scott V., Kotkiewicz, Holly, Voelker, Martin, Graves Tina, Christopher N Balakrishnan, Balakrishnan, Christopher N, Godinez, R., Warren Wesley C, Burt David W, Balakrishnan, Christopher N., Kotkiewicz Holly, Griffin, Darren K, Westerdahl, H., Balakrishnan Christopher N, Balakrishnan, C.N., Graves, T., Graves, Tina A., Burt, David W., Holly Kotkiewicz, Volker, M., Edwards Scott V   +54 more
core   +1 more source