Results 21 to 30 of about 178,249 (266)
Frontiers in Pediatrics, 2021 Background: Very few reports are available on human XX ovotesticular disorder of sex development involving SOX3 gene duplication. Here we aim to present a rare case of SOX3 gene duplication in a person from the Chinese population who exhibits XX ...
Jianlong Zhuang +9 more
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Altered patterns of gene duplication and differential gene gain and loss in fungal pathogens
BMC Genomics, 2008 Background Duplication, followed by fixation or random loss of novel genes, contributes to genome evolution. Particular outcomes of duplication events are possibly associated with pathogenic life histories in fungi.
Carbone Ignazio +4 more
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Selection in the evolution of gene duplications [PDF]
Genome Biology, 2002 Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively neutral and that, following a duplication, one of the gene copies is freed from purifying (stabilizing) selection, which creates the potential for evolution of a new function.In search of systematic
Fyodor A, Kondrashov +3 more
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Genome duplication and gene loss affect the evolution of heat shock transcription factor genes in legumes. [PDF]
PLoS ONE, 2014 Whole-genome duplication events (polyploidy events) and gene loss events have played important roles in the evolution of legumes. Here we show that the vast majority of Hsf gene duplications resulted from whole genome duplication events rather than ...
Yongxiang Lin +6 more
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Evolution of Gene Duplication in Plants [PDF]
Plant Physiology, 2016 Ancient duplication events and a high rate of retention of extant pairs of duplicate genes have contributed to an abundance of duplicate genes in plant genomes. These duplicates have contributed to the evolution of novel functions, such as the production of floral structures, induction of disease resistance, and adaptation to stress.
Nicholas Panchy +2 more
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Plant Direct, 2020 Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng +6 more
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A novel evolutionary model for constructing gene coexpression networks with comprehensive features
BMC Bioinformatics, 2019 Background Uncovering the evolutionary principles of gene coexpression network is important for our understanding of the network topological property of new genes.
Yuexi Gu, Jian Zu, Yu Li
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G3: Genes, Genomes, Genetics, 2017 Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations .
Florian Mattenberger +3 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source