Results 41 to 50 of about 3,440,639 (300)

Comparative Genomics Reveals Gene Duplication and Evolution in 26 Aurantioideae Species

Horticulturae
Gene duplication, as a prevalent phenomenon in the tree of life, provides a potential substrate for evolution. However, its role in the Aurantioideae remains unclear.
Jiaxuan Liu, Jiaxin Wu, Saimire Silaiyiman, Lejun Ouyang, Zheng Cao, Chao Shen   +5 more
doaj   +1 more source

Mechanisms of Gene Duplication and Amplification [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
Changes in gene copy number are among the most frequent mutational events in all genomes and were among the mutations for which a physical basis was first known. Yet mechanisms of gene duplication remain uncertain because formation rates are difficult to measure and mechanisms may vary with position in a genome.
Reams, Andrew B, Roth, John R
openaire   +4 more sources

Genomic studies on gene duplication.

, 2007
Using yeast Saccharomyces cerevisiae as the main model organism, I addressed three fundamental questions on gene duplication. I first investigated the functional divergence after gene duplication, revealing a general pattern of rapid subfunctionalization
He, Xionglei
core   +4 more sources

Detecting functional divergence after gene duplication through evolutionary changes in posttranslational regulatory sequences. [PDF]

PLoS Computational Biology, 2014
Gene duplication is an important evolutionary mechanism that can result in functional divergence in paralogs due to neo-functionalization or sub-functionalization.
Alex N Nguyen Ba, Bob Strome, Jun Jie Hua, Jonathan Desmond, Isabelle Gagnon-Arsenault, Eric L Weiss, Christian R Landry, Alan M Moses   +7 more
doaj   +1 more source

Comparative gene retention analysis in barley, wild emmer, and bread wheat pangenome lines reveals factors affecting gene retention following gene duplication

BMC Biology, 2023
Background Gene duplication is a prevalent phenomenon and a major driving force underlying genome evolution. The process leading to the fixation of gene duplicates following duplication is critical to understand how genome evolves but remains ...
Yong Jia, Mingrui Xu, Haifei Hu, Brett Chapman, Calum Watt, B. Buerte, Ning Han, Muyuan Zhu, Hongwu Bian, Chengdao Li, Zhanghui Zeng   +10 more
doaj   +1 more source

Glyphosate resistance and EPSPS gene duplication: convergent evolution in multiple plant species

, 2017
One of the increasingly widespread mechanisms of resistance to the herbicide glyphosate is copy number variation (CNV) of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene.
Ravet, K., Pettinga, D.J., Neve, P., Patterson, E.L., Gaines, T.A., Karl Ravet, Dean J Pettinga, Eric L Patterson, Neve, Paul, Todd A Gaines, Paul Neve   +10 more
core   +1 more source

The biased gene duplication/biased mutation (BDBM) model.

, 2022
The biased gene duplication/biased mutation (BDBM) model.
John M. Burke (8031503), John E. Bowers (11943976), Andrew H. Paterson (7361408), Haibao Tang (193781)   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Overdosage of HNF1B Gene Associated With Annular Pancreas Detected in Neonate Patients With 17q12 Duplication

Frontiers in Genetics, 2021
The annular pancreas (AP) is a congenital anomaly of the pancreas that can cause acute abdominal pain and vomiting after birth. However, the genetic cause of AP is still unknown, and no study has reported AP in patients with 17q12 duplication. This study
Feifan Xiao, Feifan Xiao, Xiuyun Liu, Xiuyun Liu, Yulan Lu, Bingbing Wu, Renchao Liu, Bo Liu, Kai Yan, Huiyao Chen, Huiyao Chen, Guoqiang Cheng, Laishuan Wang, Qi Ni, Qi Ni, Gang Li, Ping Zhang, Xiaomin Peng, Yun Cao, Chun Shen, Huijun Wang, Wenhao Zhou, Wenhao Zhou, Wenhao Zhou   +23 more
doaj   +1 more source