On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source
Genome duplication and gene loss affect the evolution of heat shock transcription factor genes in legumes. [PDF]
PLoS ONE, 2014 Whole-genome duplication events (polyploidy events) and gene loss events have played important roles in the evolution of legumes. Here we show that the vast majority of Hsf gene duplications resulted from whole genome duplication events rather than ...
Yongxiang Lin +6 more
doaj +1 more source
The low recombining pericentromeric region of barley restricts gene diversity and evolution but not gene expression [PDF]
, 2014 The low-recombining pericentromeric region of the barley genome contains roughly a quarter of the genes of the species, embedded in low recombining DNA that is rich in repeats and repressive chromatin signatures.
Dhillon, Taniya +17 more
core +1 more source
Plant Direct, 2020 Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng +6 more
doaj +1 more source
A novel evolutionary model for constructing gene coexpression networks with comprehensive features
BMC Bioinformatics, 2019 Background Uncovering the evolutionary principles of gene coexpression network is important for our understanding of the network topological property of new genes.
Yuexi Gu, Jian Zu, Yu Li
doaj +1 more source
Identification of group B respiratory syncytial viruses that lack the 60-nucleotide duplication after six consecutive epidemics of total BA dominance at coastal Kenya [PDF]
, 2013 Respiratory syncytial virus BA genotype has reportedly replaced other group B genotypes worldwide. We report the observation of three group B viruses, all identical in G sequence but lacking the BA duplication, at a coastal district hospital in Kenya in ...
Agoti, Charles N. +4 more
core +1 more source
G3: Genes, Genomes, Genetics, 2017 Gene and genome duplication are the major sources of biological innovations in plants and animals. Functional and transcriptional divergence between the copies after gene duplication has been considered the main driver of innovations .
Florian Mattenberger +3 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Pervasive developmental disorder and epilepsy due to maternally derived duplication of 15q11-q13 [PDF]
, 1999 Duplications of chromosome 15 have been reported in individuals with atypical autism, varying degrees of mental retardation, and epilepsy. The authors report the molecular analysis, neurophysiologic, and clinical evaluation of a 12-year-old boy with ...
Neri, Giovanni +2 more
core +1 more source
Simulation parameters for analysis of gene duplication. [PDF]
, 2013 Parameters for gene duplication and gene loss used to simulate the datasets for investigating the effect of gene duplication on orthology inference. These rates are per gene, per PAM unit (i.e. relative to substitutions).
Gaston H. Gonnet (18086) +3 more
core +3 more sources