Results 61 to 70 of about 321,458 (301)
Duplication, concerted evolution and purifying selection drive the evolution of mosquito vitellogenin genes [PDF]
, 2010 Background Mosquito vitellogenin (Vtg) genes belong to a small multiple gene family that encodes the major yolk protein precursors required for egg production. Multiple Vtg genes have been cloned and characterized from several mosquito species, but their
Song Chen +4 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Content based network model with duplication and divergence
, 2005 We construct a minimal content-based realization of the duplication and divergence model of genomic networks introduced by Wagner [A. Wagner, Proc. Natl. Acad. Sci.
Albert +34 more
core +1 more source
The highly rearranged mitochondrial genomes of the crabs Maja crispata and Maja squinado (Majidae) and gene order evolution in Brachyura [PDF]
, 2017 We sequenced the mitochondrial genomes of the spider crabs Maja crispata and Maja squinado (Majidae, Brachyura). Both genomes contain the whole set of 37 genes characteristic of Bilaterian genomes, encoded on both \u3b1- and \u3b2-strands.
AD Miller +67 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Inferring duplication episodes from unrooted gene trees
BMC Genomics, 2018 Background One of evolutionary molecular biology fundamental issues is to discover genomic duplication events and their correspondence to the species tree.
Jarosław Paszek, Paweł Górecki
doaj +1 more source
The divergence of alternative splicing between ohnologs in teleost fishes
BMC Ecology and Evolution, 2021 Background Gene duplication and alternative splicing (AS) are two distinct mechanisms generating new materials for genetic innovations. The evolutionary link between gene duplication and AS is still controversial, due to utilizing duplicates from ...
Yuwei Wang, Baocheng Guo
doaj +1 more source
The Roles of Gene Duplication, Gene Conversion and Positive Selection in Rodent \u3ci\u3eEsp\u3c/i\u3e and \u3ci\u3eMup\u3c/i\u3e Pheromone Gene Families with Comparison to the \u3ci\u3eAbp\u3c/i\u3e Family [PDF]
, 2012 Three proteinaceous pheromone families, the androgen-binding proteins (ABPs), the exocrine-gland secreting peptides (ESPs) and the major urinary proteins (MUPs) are encoded by large gene families in the genomes of Mus musculus and Rattus norvegicus.
Karn, Robert C., Laukaitis, Christina M.
core +4 more sources
Functional divergence of duplicate genes several million years after gene duplication in Arabidopsis [PDF]
DNA Research, 2018 Lineage-specific duplicated genes likely contribute to the phenotypic divergence in closely related species. However, neither the frequency of duplication events nor the degree of selection pressures immediately after gene duplication is clear in the speciation process.
Hanada, Kousuke +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source