Results 51 to 60 of about 3,440,639 (300)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Additional TreeFam gene duplication data with duplication timing

, 2015
Additional TreeFam gene duplication data with duplication ...
Lukasz Huminiecki (28016), Consortium Fantom (3264798), Forrest, Alistair R. R., Fantom, Consortium, Avazeh T. Ghanbarian (839004), Hurst, Laurence D., Ghanbarian, Avazeh T., Laurence D. Hurst (42488), Huminiecki, Lukasz, Alistair R. R. Forrest (185918)   +9 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Exonic duplication of the OTC gene by a complex rearrangement that likely occurred via a replication-based mechanism: a case report

BMC Medical Genetics, 2018
Background Ornithine transcarbamylase deficiency (OTCD) is an X-linked recessive disorder involving a defect in the urea cycle caused by OTC gene mutations.
Katsuyuki Yokoi, Yoko Nakajima, Hidehito Inagaki, Makiko Tsutsumi, Tetsuya Ito, Hiroki Kurahashi   +5 more
doaj   +1 more source

The low recombining pericentromeric region of barley restricts gene diversity and evolution but not gene expression [PDF]

, 2014
The low-recombining pericentromeric region of the barley genome contains roughly a quarter of the genes of the species, embedded in low recombining DNA that is rich in repeats and repressive chromatin signatures.
Dhillon, Taniya, Milne, Iain, Baker, Katie, Colas, Isabelle, Bayer, Micha, Russell, Joanne, Marshall, David, Waugh, Robbie, Dreißig, Steven, Flavell, Andrew J., Ramsay, Luke, Steffenson, Brian, Stephen, Gordon, Dressig, Steven, Hedley, Pete E., Waugh, Robbie; id_orcid, Cook, Nicola, Morris, Jenny, Cook, Nicola; id_orcid   +18 more
core   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Maximum likelihood models and algorithms for gene tree evolution with duplications and losses

BMC Bioinformatics, 2011
Background The abundance of new genomic data provides the opportunity to map the location of gene duplication and loss events on a species phylogeny. The first methods for mapping gene duplications and losses were based on a parsimony criterion, finding ...
Burleigh Gordon J, Górecki Pawel, Eulenstein Oliver   +2 more
doaj   +1 more source

Ka Ks values and gene duplication of GmSS paralogous gene pairs.

, 2022
Ka Ks values and gene duplication of GmSS paralogous gene pairs.
Helena Dvořáčková (12066066), Shakeel Ahmed (3176139), Hafiz Ishfaq Ahmad (6599714), Jamal Abdul Nasir (7507505), Abdullah Ahmed Al-Ghamdi (12152930), Bushra Ahmad (12152927), Jan Dvořáček (12066069), Mohamed S. Elshikh (7636061), Zamarud Shah (12152924), Arshad Jamil (12152933), Muhammad Zulfiqar Ahmad (9026207), Asma Gul (5980553)   +11 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source