Results 301 to 310 of about 8,339,405 (403)

Gene Editing of Pluripotent Stem Cell-Derived Hepatic Cells for Liver Disease Modeling and Therapeutic Development. [PDF]

Biomol Ther (Seoul)
Lim D, Kim HR.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Retinal organoids mirror CRISPR-Cas9 gene editing efficiency observed <i>in vivo</i>. [PDF]

Mol Ther Methods Clin Dev
Pulman J, Malki H, Oudin P, Aydin E, Tran S, Visticot L, Robert C, De Cian A, As M, Goureau O, Concordet JP, Dalkara D.   +11 more
europepmc   +1 more source

Crispr-Based Gene Editing: Ethical Considerations and Future Prospects in Medicine

Anoop Dev, Sidhant Das, Ezhilarasan Ganesan, Shivangi Gupta, S. N. Upadhyay, Chinmaya Kumar Mohapatra, M. Abilasha   +6 more
openalex   +2 more sources

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

In situ gene editing of hematopoietic stem cells via AAV-delivered CRISPR guide RNAs. [PDF]

Blood Adv
Karimzadeh A, Kim R, Garcia V, Florea M, Peacker BL, Kobayashi S, Watkins D, Messemer K, Zeng J, Bauer DE, Serwold T, Wagers AJ.   +11 more
europepmc   +1 more source

Additional file 1 of Phenotypes in Brugada syndrome with different genotypes triggered by fever or inflammation using gene-edited iPSCs

Li, Yingrui, Rose, Lena, Prädel, Timo, Kleinsorge, Mandy, Fan, Xuehui, Meng, Zenghui, Yan, Chen, Liu, Rui, Lei, Xinhao, Zhao, Binyi, Yang, Guoqiang, Liao, Zhenxing, Dinkel, Hendrik, Busley, Alexandra Viktoria, Zhong, Rujia, Zhang, Feng, Xu, Qiang, Maywald, Lasse, Aweimer, Assem, Huang, Mengying, Moscu-Gregor, Alexander, Hamdani, Nazha, Schneider, Luca, Zemedi, Yeweynwuha, Zhazykbayeva, Saltanat, Hohn, Alyssa, Yang, Zhen, Qiao, Lin, Mügge, Andreas, Cyganek, Lukas, Zhou, Xiaobo, Akin, Ibrahim, El-Battrawy, Ibrahim   +32 more
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Gene editing for collagen disorders: current advances and future perspectives. [PDF]

Gene Ther
Kocsy K, Wilkinson H, Felix-Ilemhenbhio F, Bax B, Van Agtmael T, Azzouz M, Majid A.   +6 more
europepmc   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source