Results 111 to 120 of about 2,669,754 (369)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Delivery of human apolipoprotein (apo) E to liver by an [E1(-), E3(-), polymerase(-), pTP(-)] adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

, 2006
Recombinant adenovirus (rAd)-mediated apoE gene transfer to the liver of apoE(-/-) mice is anti-atherogenic. However, first generation rAd vectors were associated with immune clearance of transduced hepatocytes, while an improved [E1(-), E3(-) polymerase(
Amalfitano, A, Owen, JS, Dickson, G, Graham, IR, Harris, JD   +4 more
core  

Early selection for drought tolerance in popcorn based on gene effects estimated in seedlings. [PDF]

Front Plant Sci, 2023
Carvalho CM, Khan S, Teixeira do Amaral Junior A, de Lima VJ, de Souza Silva JG, Catarino Fuly LM, Leite JT, Dos Santos Junior DR, Viana FN, de Souza R, Vieira HD, Kamphorst SH.   +11 more
europepmc   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Host gene effects on gut microbiota in type 1 diabetes. [PDF]

Biochem Soc Trans, 2022
Guo K, Huang J, Zhou Z.
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Investigation Of Gene Delivery Via Silicon Nanotubes Using The Reporter Gene Egfp

, 2015
With the rising prominence of nanotechnology, materials such as silicon nanotubes offer great potential in a wide variety of fields. On such a small scale, the physical and chemical properties of the constituent elements are dramatically changed.
Szymanski, Kyle
core  

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

, 2020
Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient.
Ludmila V. Akhmadishina, Marina I. Beloukhova, Alexander N. Lukashev, Vadim V. Tarasov, Yulia A. Vakulenko, Andrey A. Zamyatnin Jr., Andrei A. Deviatkin   +6 more
core   +1 more source

Unraveling the Regulatory Mechanisms Underlying Tissue-Dependent Genetic Variation of Gene Expression [PDF]

, 2012
It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression.
Harry J M Groen, Veldink, Jan,, Meerman, Gerard J. te,, Groen, Harry JM, Westra, Harm-Jan,, Ophoff, Roel A.,, Wolfs, Marcel G.M.,, Snieder, Harold; id_orcid, Fehrmann, Rudolf S.N.,, Fu, J, Harry J. M. Groen (101726), Groen, H.J., Fu, Jingyuan, Westra, Harm Jan, Wolfs Marcel G. M., Patrick Deelen, Westra, Harm Jan; id_orcid, Wim A Buurman, van Heel David, Weersma, RK, Groen, Harry J.M.,, Marcel G M Wolfs, Marten H. Hofker (102396), Buurman Wim A., Patrick Deelen (187548), Jansen, R.C., Fehrmann, R.S., Weersma, Rinse K; id_orcid, Harm-Jan Westra, Jansen, Ritsert C, Wijmenga, Cisca, Meerman, GJT, Cisca Wijmenga, Gerard J Te Meerman, Franke, L, Fehrmann, RSN, Rensen, SSM, Wolfs, MGM, Jingyuan Fu (102399), Weersma, Rinse K.,, Rinse K. Weersma (131692), van den Berg, Leonard H, Harold Snieder (103613), Rensen, Sander S.M.,, Fu, Jingyuan,, Fehrmann, Rudolf S N, Rensen, Sander S M, van den Berg, L.H., Sander S. M. Rensen (187559), van den Berg Leonard H., Snieder Harold, Heel, David van,, Snieder, Harold,, Leonard H van den Berg, te Meerman, G.J., te Meerman Gerard J., Ritsert C Jansen, Wolfs, M.G., Deelen, Patrick, Snieder, H., Fu Jingyuan, Deelen, P., Cisca Wijmenga (32954), Weersma, R.K., Wijmenga, Cisca,, Roel A. Ophoff (155472), Wim A. Buurman (162734), Fu, Jingyuan; id_orcid, Franke, L., Groen, Hendricus, Ophoff, RA, Wolfs, Marcel GM, Wolfs, Marcel G M, Hofker Marten H., Buurman, WA, Leonard H. van den Berg (119440), van Heel, D., Westra, H-J, Hofker, MH, Lude Franke (102406), Buurman, W.A., Jan Veldink, Groen Harry J. M., Wijmenga, C., Wijmenga Cisca, Veldink, Jan, Meerman, Gerard J te, Lude Franke, Weersma, Rinse K, Jansen, Ritsert C.,, Sander S M Rensen, Wijmenga, C, Harm-Jan Westra (102374), Westra, H.J., Veldink, J., van den Berg, LH, Snieder, Harold, David van Heel (187571), Harold Snieder, David van Heel, Westra, Harm-Jan, Rudolf S. N. Fehrmann (87558), Westra Harm-Jan, Ophoff, Roel A, Deelen Patrick, Berg, Leonard H. van den,, Rensen Sander S. M., Fehrmann, Rudolf SN, Wijmenga, Cisca; id_orcid, Roel A Ophoff, Franke, Lude, Buurman, Wim A.,, Rensen, S.S.M.; id_orcid, Groen, HJM, Ritsert C. Jansen (32125), Deelen, Patrick,, van Heel, David, Rensen, Sander SM, Franke, Lude,, Rensen, S.S.M., Weersma Rinse K., Hofker, Marten H.,, Fehrmann Rudolf S. N., Franke Lude, Jan Veldink (187567), Hofker, M.H., van Heel, D, Snieder, H, Rudolf S N Fehrmann, Buurman, Wim A, Hofker, Marten H, Deelen, P, Marten H Hofker, Veldink Jan, Jingyuan Fu, Veldink, J, Rinse K Weersma, Marcel G. M. Wolfs (187544), Jansen Ritsert C., Ophoff, R.A., Jansen, RC, Gerard J. te Meerman (87570), te Meerman, Gerhardus, Ophoff Roel A., Groen, Hendricus; id_orcid, Fu, J.   +145 more
core   +1 more source

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. [PDF]

Am Heart J Plus, 2022
Dungan JR, Qin X, Gregory SG, Cooper-Dehoff R, Duarte JD, Qin H, Gulati M, Taylor JY, Pepine CJ, Hauser ER, Kraus WE.   +10 more
europepmc   +1 more source