Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2013 The in vivo accessibility of the chick embryo makes it a favoured model system for experimental developmental biology. Although the range of available techniques now extends to miss-expression of genes through in ovo electroporation, it remains difficult
Bueno i Torrens, David, 1965- +1 more
core
Inheritance of yield and yield components in soybean (Glycine max (L.) Merrill.)
Electronic Journal of Plant Breeding, 2017 The present investigation was undertaken to study the genetics of yield and yield components in soybean through generation mean analysis. Three crosses viz., MACS-450 × Monetta, DS-9712 × Kalitur and MACS-450 × Kalitur were made involving four parents ...
D.S. Thakare +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Shifts in Gene Expression Variability in the blood-stage of Plasmodium relictum [Elektronisk resurs]
, 2021 Avian malaria is a common and widespread disease of birds caused by a diverse group of pathogens of the genera Plasmodium. We investigated the transcriptomal profiles of one of the most common species, Plasmodium relictum, lineage SGS1, at multiple ...
Hellgren, Olof, +5 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Breeding potential of the field pea (Pisum sativum L.) cultivars and their progenies [PDF]
Journal of BioScience and Biotechnology, 2014 The inheritance and gene effects structure were investigated for ten quantitative traits in field cultivars by a full diallel model of four parents – the cultivars Kerpo, Pleven 10, Mir and EFB33.
Valentin Kosev
doaj
POEM: Identifying joint additive effects on regulatory circuits
Frontiers in Genetics, 2016 Motivation: Expression Quantitative Trait Locus (eQTL) mapping tackles the problem of identifying variation in DNA sequence that have an effect on the transcriptional regulatory network.
Maya eBotzman +3 more
doaj +1 more source
Analyzing aberrant DNA methylation in colorectal cancer uncovered intangible heterogeneity of gene effects in the survival time of patients. [PDF]
Sci Rep, 2023 Hajebi Khaniki S +3 more
europepmc +1 more source
Near isogenic lines (NIL) of sorghum carrying wild type or waxy alleles of the granule-bound starch synthase (GBSS) gene have distinct effects on human gut microbiome phenotypes and host physiological characteristics [PDF]
, 2022 Qinnan Yang +12 more
openalex +1 more source