Results 51 to 60 of about 2,170,661 (326)

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

G3: Genes, Genomes, Genetics, 2017
The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used to ...
Traver Hart, A. Tong, Katie Chan, Jolanda van Leeuwen, Ashwin Seetharaman, Michael Aregger, M. Chandrashekhar, Nicole Hustedt, S. Seth, Avery J. C. Noonan, Andrea Habsid, O. Sizova, L. Nedyalkova, R. Climie, Leanne Tworzyanski, K. Lawson, M. A. Sartori, Sabriyeh Alibeh, D. Tieu, Sanna N. Masud, P. Mero, Alexander Weiss, K. Brown, Matej Ušaj, Maximilian Billmann, Mahfuzur Rahman, M. Costanzo, C. Myers, B. Andrews, Charles Boone, D. Durocher, J. Moffat   +31 more
semanticscholar   +1 more source

A phase synchronization clustering algorithm for identifying interesting groups of genes from cell cycle expression data

BMC Bioinformatics, 2008
Background The previous studies of genome-wide expression patterns show that a certain percentage of genes are cell cycle regulated. The expression data has been analyzed in a number of different ways to identify cell cycle dependent genes. In this study,
Tcha Hong, Bae Cheol, Kim Chang
doaj   +1 more source

Molecular signatures of tumor progression in pancreatic adenocarcinoma identified by energy metabolism characteristics

BMC Cancer, 2022
Background In this study, we performed a molecular evaluation of primary pancreatic adenocarcinoma (PAAD) based on the comprehensive analysis of energy metabolism-related gene (EMRG) expression profiles.
Cong Tan, Xin Wang, Xu Wang, Weiwei Weng, Shu-juan Ni, Meng Zhang, Hesheng Jiang, Lei Wang, Dan Huang, Weiqi Sheng, Mi-die Xu   +10 more
doaj   +1 more source

A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data [PDF]

, 2015
A major theme in constraint-based modeling is unifying experimental data, such as biochemical information about the reactions that can occur in a system or the composition and localization of enzyme complexes, with highthroughput data including ...
Barker, Brandon, Gu, Zhenglong, Locasale, Jason W., Myers, Christopher R., Sadagopan, Narayanan, Smallbone, Kieran, Wang, Yiping, Xi, Hongwei   +7 more
core   +2 more sources

The evaluation of an identification algorithm for Mycobacterium species using the 16S rRNA coding gene and rpoB

International Journal of Mycobacteriology, 2012
Conventional biochemical tests are the standard for the identification of Mycobacterium species, but molecular identifications are becoming more prevalent. The rpoB gene encodes the β-subunit of RNA polymerase and is utilized for the identification of Mycobacterium species. In the present study, a stepwise Mycobacterium species identification algorithm
Yuko Kazumi, Satoshi Mitarai
openaire   +3 more sources

An Evaluation of Information Technology of Gene Expression Profiles Processing Stability for Different Levels of Noise Component

, 2018
The paper presents the results of the research concerning an evaluation of information 1 technology of gene expression profiles processing stability with the use of gene expression profiles 2 with different levels of noise component.
S. Babichev
semanticscholar   +1 more source

Evolving Deep Convolutional Neural Networks for Image Classification [PDF]

IEEE Transactions on Evolutionary Computation, 2017
Evolutionary paradigms have been successfully applied to neural network designs for two decades. Unfortunately, these methods cannot scale well to the modern deep neural networks due to the complicated architectures and large quantities of connection ...
Y. Sun, Bing Xue, Mengjie Zhang, G. Yen
semanticscholar   +1 more source

The use of RNAIII inhibitory peptide in the treatment of elderly patients with staphylococcus aureus infection and construction of fuzzy mathematical model for curative effect evaluation

Results in Physics, 2021
The study aims to explore application of RNAIII inhibiting peptide (RIP) and image information counting algorithm in the rehabilitation treatment plan of staphylococcus aureus infection in old people’s bone and joint.
Hong Ye, Lihong Wu, Wangyuan Zhang, Jianrong Li, Xiaomin Sun, Chunxia Chen, Yuxia Sun, Jinfeng Han   +7 more
doaj   +1 more source

Stable Feature Selection for Biomarker Discovery [PDF]

, 2010
Feature selection techniques have been used as the workhorse in biomarker discovery applications for a long time. Surprisingly, the stability of feature selection with respect to sampling variations has long been under-considered.
He, Zengyou, Yu, Weichuan
core   +2 more sources

Comparative evaluation of isoform-level gene expression estimation algorithms for RNA-seq and exon-array platforms [PDF]

Briefings in Bioinformatics, 2016
Given that the majority of multi-exon genes generate diverse functional products, it is important to evaluate expression at the isoform level. Previous studies have demonstrated strong gene-level correlations between RNA sequencing (RNA-seq) and microarray platforms, but have not studied their concordance at the isoform level.
Matthew Dapas, Manoj Kandpal, Yingtao Bi, Ramana V. Davuluri   +3 more
openaire   +2 more sources