Results 31 to 40 of about 4,531,065 (206)

Transcriptional coupling of neighbouring genes and gene expression noise: evidence that gene orientation and non-coding transcripts are modulators of noise [PDF]

, 2010
For some genes, notably essential genes, expression when expression is needed is vital hence low noise in expression is favourable. For others noise is necessary for coping with stochasticity or for providing dice-like mechanisms to control cell fate ...
Guang-Zhong Wang, Laurence D. Hurst, Martin J. Lercher   +2 more
core   +2 more sources

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]

, 2019
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G, Eskin, Eleazar, Graeber, Thomas G, Yao, Douglas W   +3 more
core  

Gene co-expression networks of hepatic tissue associated with ribeye area in Nellore cattle. [PDF]

, 2023
The ribeye area (REA) shows a positive correlation with carcass weight and animal growth, making it a reliable indicator of muscularity, prime cuts, and the overall edible mass of the ...
AFONSO, J., CESAR, A. S. M., COUTINHO, L. L., FUKUMASU, H., GARCIA, I. S., LIMA, B. D., REGITANO, L. C. de A., SILVA, S. da L. e S., SILVA, T. R. da, SILVA-VIGNATO, B.   +9 more
core  

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. [PDF]

, 2016
BackgroundUBE4B is an E3/E4 ubiquitin ligase whose gene is located in chromosome 1p36.22. We analyzed the associations of UBE4B gene and protein expression with neuroblastoma patient outcomes and with tumor prognostic features and histology.MethodsWe ...
Bean, Andrew J, Guo, Rong Jun, Hollingsworth, Emporia Faith, Indiviglio, Sandra, Ittmann, Michael, Liu, Yin, Lopez-Terrada, Dolores, Major, Angela M, Mo, Qianxing, Whittle, Sarah B, Woodfield, Sarah E, Zage, Peter E   +11 more
core   +2 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. [PDF]

, 2017
Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during ...
Ao, Yan, Burda, Josh, Farkhondeh, Vista, Itoh, Noriko, Itoh, Yuichiro, Johnsonbaugh, Hadley, Kaito, Max, Ohno, Ai, Ren, Emily, Sofroniew, Michael V, Tassoni, Alessia, Voskuhl, Rhonda R   +11 more
core   +2 more sources

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Towards knowledge-based gene expression data mining [PDF]

, 2007
The field of gene expression data analysis has grown in the past few years from being purely data-centric to integrative, aiming at complementing microarray analysis with data and knowledge from diverse available sources. In this review, we report on the
Allison, Andersson, Ashburner, Bar-Joseph, Bar-Joseph, Batagelj, Bernard, Blaž Zupan, Bolshakova, Brown, Cheng, Cheng, Cho, Clayton, Cooper, Curk, Datta, de Jong, D’Haeseleer, Eisen, Falcon, Friedman, Gamberger, Gavin, Geiger, Guo, Hand, Hand, Hastie, Huang, Hughes, Hughes, Hvidsten, Imoto, Jeffery, Jiang, Khan, Khatri, King, Kong, Lai, Le Phillip, Li, Liang, Lin, Mewes, Mitchell, Moskovitch, Nariai, Pan, Prelic, Qin, Raftery, Resnik, Riccardo Bellazzi, Riva, Rousu, Ruepp, Sacchi, Schlitt, Sebastiani, Shahar, Simon, Statnikov, Stuart, Subramanian, Tamada, Tamayo, Troyanskaya, van de Peppel, Van Driessche, Wang, Witten, Xing, Zupan   +74 more
core   +1 more source