Results 51 to 60 of about 5,342,886 (354)

Towards knowledge-based gene expression data mining [PDF]

, 2007
The field of gene expression data analysis has grown in the past few years from being purely data-centric to integrative, aiming at complementing microarray analysis with data and knowledge from diverse available sources. In this review, we report on the
Allison, Andersson, Ashburner, Bar-Joseph, Bar-Joseph, Batagelj, Bernard, Blaž Zupan, Bolshakova, Brown, Cheng, Cheng, Cho, Clayton, Cooper, Curk, Datta, de Jong, D’Haeseleer, Eisen, Falcon, Friedman, Gamberger, Gavin, Geiger, Guo, Hand, Hand, Hastie, Huang, Hughes, Hughes, Hvidsten, Imoto, Jeffery, Jiang, Khan, Khatri, King, Kong, Lai, Le Phillip, Li, Liang, Lin, Mewes, Mitchell, Moskovitch, Nariai, Pan, Prelic, Qin, Raftery, Resnik, Riccardo Bellazzi, Riva, Rousu, Ruepp, Sacchi, Schlitt, Sebastiani, Shahar, Simon, Statnikov, Stuart, Subramanian, Tamada, Tamayo, Troyanskaya, van de Peppel, Van Driessche, Wang, Witten, Xing, Zupan   +74 more
core   +1 more source

Loss of TET2 and TET3 in regulatory T cells unleashes effector function

Nature Communications, 2019
Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells ...
Xiaojing Yue, Chan-Wang J. Lio, Daniela Samaniego-Castruita, Xiang Li, Anjana Rao   +4 more
doaj   +1 more source

Hybridization and gene expression: Beyond differentially expressed genes

Molecular Ecology
AbstractGene expression has a key role in reproductive isolation, and studies of hybrid gene expression have identified mechanisms causing hybrid sterility. Here, we review the evidence for altered gene expression following hybridization and outline the mechanisms shown to contribute to altered gene expression in hybrids. Transgressive gene expression,
Runemark, Anna, Moore, Emily C., Larson, Erica L.   +2 more
openaire   +3 more sources

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity

Nature Communications, 2021
Transcriptional state plays a role in genome organization, however factors that link these processes are not well known. Here, the authors show Drosophila transcription factor Motif 1-binding protein (M1BP) interacts with the insulator protein CP190 to ...
Indira Bag, Shue Chen, Leah F. Rosin, Yang Chen, Chen-Yu Liu, Guo-Yun Yu, Elissa P. Lei   +6 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]

, 2019
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G, Eskin, Eleazar, Graeber, Thomas G, Yao, Douglas W   +3 more
core  

Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]

, 2015
The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R, Harrison, PW, Mank, JE, Wright, AE, Zimmer, F   +4 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Insanity as a Defense to the Civil Fraud Penalty [PDF]

, 1963
Most neurological diseases are associated with chronic inflammation initiated by the activation of microglia, which produce cytotoxic and inflammatory factors.
Dabrowski, Michal, Ellert-Miklaszewska, Aleksandra, Hu, Feng, Kaminska, Bozena, Kaza, Beata, Kettenmann, Helmut, Kloss, Michal, Komorowski, Jan, Mieczkowski, Jakub, Piotrowski, Arkadiusz, Przanowski, Piotr, Ronowicz, Anna   +11 more
core   +2 more sources