Results 51 to 60 of about 13,983,545 (429)

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing [PDF]

PeerJ, 2013
Exosomes are nanosized (30–100 nm) membrane vesicles secreted by most cell types. Exosomes have been found to contain various RNA species including miRNA, mRNA and long non-protein coding RNAs. A number of cancer cells produce elevated levels of exosomes.
Piroon Jenjaroenpun, Yuliya Kremenska, Vrundha M. Nair, Maksym Kremenskoy, Baby Joseph, Igor V. Kurochkin   +5 more
doaj   +2 more sources

Quantifying Gene Expression [PDF]

Current Issues in Molecular Biology, 2002
Identifying those genes that are expressed and at what levels is an essential part of almost any biological inquiry at the cellular level. Techniques such as Northern blot have been in existence for decades to perform this task, but advances in molecular biology and bioinstrumentation have led to the development of a variety of new techniques with a ...
openaire   +3 more sources

Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets

BMC Genomics, 2017
Background High-grade serous ovarian carcinoma (HG-SOC) is the dominant tumor histologic type in epithelial ovarian cancers, exhibiting highly aberrant microRNA expression profiles and diverse pathways that collectively determine the disease ...
Vladimir A. Kuznetsov, Zhiqun Tang, Anna V. Ivshina   +2 more
doaj   +1 more source

Identifying expressed genes [PDF]

Proceedings of the National Academy of Sciences, 2000
The study of expressed genes has had a great impact on biological research (1). Expressed genes are the basic functional units of genomic DNA. Because these regions cannot be identified from genomic sequence information per se, the gene's products, messenger RNAs or proteins, must be isolated from cells, directly sequenced, and identified.
Katherine J. Martin, Arthur B. Pardee
openaire   +3 more sources

Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]

, 2015
The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Dean, R, Harrison, PW, Mank, JE, Wright, AE, Zimmer, F   +4 more
core   +1 more source

Repeated observation of breast tumor subtypes in independent gene expression data sets

Proceedings of the National Academy of Sciences of the United States of America, 2003
Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we have refined the previously defined subtypes of breast tumors that could be distinguished by ...
T. Sørlie, R. Tibshirani, Joel Parker, T. Hastie, J. Marron, A. Nobel, Shibing Deng, H. Johnsen, Robert Pesich, S. Geisler, J. Demeter, C. Perou, P. Lønning, P. Brown, A. Børresen-Dale, D. Botstein   +15 more
semanticscholar   +1 more source

SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells

Nature Communications, 2018
The mechanism of resistance to EZH2 inhibitors in cancers with inactivating SWI/SNF mutations is unknown. Here, the authors demonstrate that the switch of the SWI/SNF catalytic subunits from SMARCA4 to SMARCA2 drives resistance to EZH2 inhibitors in ...
Shuai Wu, Nail Fatkhutdinov, Takeshi Fukumoto, Benjamin G. Bitler, Pyoung Hwa Park, Andrew V. Kossenkov, Marco Trizzino, Hsin-Yao Tang, Lin Zhang, Alessandro Gardini, David W. Speicher, Rugang Zhang   +11 more
doaj   +1 more source

A gene-expression signature as a predictor of survival in breast cancer.

New England Journal of Medicine, 2002
BACKGROUND A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy. METHODS Using microarray analysis to evaluate our previously established 70-gene prognosis profile, we classified
M. J. van de Vijver, Yudong He, L. J. van ’t Veer, H. Dai, A. Hart, D. Voskuil, G. Schreiber, J. Peterse, C. Roberts, M. Marton, M. Parrish, D. Atsma, A. Witteveen, A. Glas, L. Delahaye, Tony van der Velde, H. Bartelink, S. Rodenhuis, E. Rutgers, S. Friend, René Bernards   +20 more
semanticscholar   +1 more source

Inhibiting stromal Class I HDACs curbs pancreatic cancer progression

Nature Communications, 2023
Oncogenic lesions in pancreatic ductal adenocarcinoma (PDAC) hijack the epigenetic machinery in stromal components to establish a desmoplastic and therapeutic resistant tumor microenvironment (TME).
Gaoyang Liang, Tae Gyu Oh, Nasun Hah, Hervé Tiriac, Yu Shi, Morgan L. Truitt, Corina E. Antal, Annette R. Atkins, Yuwenbin Li, Cory Fraser, Serina Ng, Antonio F. M. Pinto, Dylan C. Nelson, Gabriela Estepa, Senada Bashi, Ester Banayo, Yang Dai, Christopher Liddle, Ruth T. Yu, Tony Hunter, Dannielle D. Engle, Haiyong Han, Daniel D. Von Hoff, Michael Downes, Ronald M. Evans   +24 more
doaj   +1 more source

Origins of Binary Gene Expression in Post-transcriptional Regulation by MicroRNAs

, 2012
MicroRNA-mediated regulation of gene expression is characterised by some distinctive features that set it apart from unregulated and transcription factor-regulated gene expression. Recently, a mathematical model has been proposed to describe the dynamics
Bose, Indrani, Ghosh, Sayantari
core   +1 more source