Results 61 to 70 of about 5,533,099 (347)

Chemical combinations potentiate human pluripotent stem cell-derived 3D pancreatic progenitor clusters toward functional β cells

open access: yesNature Communications, 2021
Human pluripotent stem cell (hPSC) derived pancreatic beta cells are a promising and potentially limitless source for cell replacement therapy.
Haisong Liu   +11 more
doaj   +1 more source

Positive Feedback, Stochasticity and Genetic Competence

open access: yes, 2007
A single gene, regulating its own expression via a positive feedback loop, constitutes a common motif in gene regulatory networks and signalling cascades. Recent experiments on the development of competence in the bacterial population \emph{B.
Bose, Indrani, Karmakar, Rajesh
core   +1 more source

A microfluidic processor for gene expression profiling of single human embryonic stem cells [PDF]

open access: yes, 2008
The gene expression of human embryonic stem cells (hESC) is a critical aspect for understanding the normal and pathological development of human cells and tissues.
Chen, Yan   +6 more
core   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed   +5 more
wiley   +1 more source

Novel biosensor for high-throughput detection of progesterone receptor-interacting endocrine disruptors

open access: yesScientific Reports
Progesterone receptor (PR)-interacting compounds in the environment are associated with serious health hazards. However, methods for their detection in environmental samples are cumbersome.
Diana A. Stavreva   +5 more
doaj   +1 more source

Structural basis underlying viral hijacking of a histone chaperone complex

open access: yesNature Communications, 2016
The Epstein-Barr virus tegument protein BNRF1 is required for the establishment of selective viral gene expression during latency and interacts with the histone chaperone DAXX.
Hongda Huang   +6 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

open access: yesFEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

open access: yesNature Communications, 2017
MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus ...
Silvia Bottini   +11 more
doaj   +1 more source

Decrease in gyrase A protein expression in _E. coli_ cells inhibited by antisense ribozymes [PDF]

open access: yes, 2008
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies represent promising strategies for specific inhibition of
Malathi Raghunathan   +1 more
core   +1 more source

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