Results 61 to 70 of about 5,153,058 (200)

Proximity labeling identifies a repertoire of site-specific R-loop modulators

Nature Communications, 2022
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma   +6 more
doaj   +1 more source

Positive Feedback, Stochasticity and Genetic Competence

, 2007
A single gene, regulating its own expression via a positive feedback loop, constitutes a common motif in gene regulatory networks and signalling cascades. Recent experiments on the development of competence in the bacterial population \emph{B.
Bose, Indrani, Karmakar, Rajesh
core   +1 more source

SAGA–CORE subunit Spt7 is required for correct Ubp8 localization, chromatin association and deubiquitinase activity

Epigenetics & Chromatin, 2020
Background Histone H2B deubiquitination is performed by numerous deubiquitinases in eukaryotic cells including Ubp8, the catalytic subunit of the tetrameric deubiquitination module (DUBm: Ubp8; Sus1; Sgf11; Sgf73) of the Spt-Ada-Gcn5 acetyltransferase ...
Carme Nuño-Cabanes, Varinia García-Molinero, Manuel Martín-Expósito, María-Eugenia Gas, Paula Oliete-Calvo, Encar García-Oliver, María de la Iglesia-Vayá, Susana Rodríguez-Navarro   +7 more
doaj   +1 more source

ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle

Cell Reports, 2018
Summary: PGC1α is a pleiotropic co-factor that affects angiogenesis, mitochondrial biogenesis, and oxidative muscle remodeling via its association with multiple transcription factors, including the master oxidative nuclear receptor ERRγ.
Weiwei Fan, Nanhai He, Chun Shi Lin, Zong Wei, Nasun Hah, Wanda Waizenegger, Ming-Xiao He, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Ronald M. Evans   +11 more
doaj   +1 more source

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development

Scientific Reports, 2017
Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C.
Sarah-Lena Offenburger, Dalila Bensaddek, Alejandro Brenes Murillo, Angus I. Lamond, Anton Gartner   +4 more
doaj   +1 more source

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Protein & Cell, 2019
Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion.
Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Ignacio Sancho-Martinez, Yuta Takahashi, Fumiyuki Hatanaka, Jun Wu, Alejandro Ocampo, Pradeep Reddy, Min-Zu Wu, Laurie Gerken, Reuben J. Shaw, Concepcion Rodriguez Esteban, Christopher Benner, Hiroshi Nakagawa, Pedro Guillen Garcia, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Guang-Hui Liu, Juan Carlos Izpisua Belmonte   +20 more
doaj   +1 more source

Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading

Nature Communications, 2017
The cytokines IL-1β and IL-6 mediate the systemic acute phase response (APR). Here, the authors provide evidence that these cytokines lead to both synergistic and antagonistic gene expression during APR; synergistic induction occurs by assisted loading ...
Ido Goldstein, Ville Paakinaho, Songjoon Baek, Myong-Hee Sung, Gordon L. Hager   +4 more
doaj   +1 more source

The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element

Genome Biology, 2017
Background It is now obvious that the majority of cellular transcripts do not code for proteins, and a significant subset of them are long non-coding RNAs (lncRNAs).
Oskar Marín-Béjar, Aina M. Mas, Jovanna González, Dannys Martinez, Alejandro Athie, Xabier Morales, Mikel Galduroz, Ivan Raimondi, Elena Grossi, Shuling Guo, Ana Rouzaut, Igor Ulitsky, Maite Huarte   +12 more
doaj   +1 more source

TNF-alpha inhibition ameliorates HDV-induced liver damage in a mouse model of acute severe infection

JHEP Reports, 2020
Background & Aims: HDV infection induces the most severe form of human viral hepatitis. However, the specific reasons for the severity of the disease remain unknown.
Carla Usai, Sheila Maestro, Gracian Camps, Cristina Olague, Lester Suárez-Amaran, Africa Vales, Tomas Aragon, Mirja Hommel, Rafael Aldabe, Gloria Gonzalez-Aseguinolaza   +9 more
doaj   +1 more source

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. [PDF]

, 2020
BackgroundGlobal gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment-specific ...
Burchard, Esteban G, Croteau-Chonka, Damien C, Dahlin, Amber, Eng, Celeste, Kelly, Rachel, Kho, Alvin T, Lu, Quan, Lutz, Sharon M, Mak, Angel CY, McGeachie, Michael J, Oh, Sam S, Panganiban, Ronald, Raby, Benjamin A, Rodriguez-Santana, Jose R, Saef, Benjamin, Sajuthi, Satria, Seibold, Max A, Sordillo, Joanne E, Tantisira, Kelan G, Urbanek, Cydney, Wang, Alberta L, Weiss, Scott T, Wu, Ann Chen   +22 more
core   +1 more source