Results 221 to 230 of about 1,715,800 (269)
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Regulating gene expression in gene therapy
Trends in Biotechnology, 1993Ensuring that expression of introduced genes is both safe and effective necessitates directing expression to the appropriate tissue, at levels which produce a therapeutic effect. Extensive research is under way to elucidate the mechanisms and genetic elements involved in regulating expression. With the need to correlate expression levels and phenotypic
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Regulation of gene expression by hypoxia
Biochemical Journal, 2008Hypoxia induces profound changes in the cellular gene expression profile. The discovery of a major transcription factor family activated by hypoxia, HIF (hypoxia-inducible factor), and the factors that contribute to HIF regulation have greatly enhanced our knowledge of the molecular aspects of the hypoxic response.
Kenneth, Niall Steven, Rocha, Sonia
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Androgen regulation of gene expression
The Prostate, 1996Androgen receptors are important transcription factors regulating the expression of a number of genes in androgen-responsive cells and may play a role in prostate cancer. This article describes transcriptional suppressors and other transcription factors which may play important roles in modulating the expression of androgen receptors.
J E, Perry, M E, Grossmann, D J, Tindall
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Regulation of gene expression by light
Current Opinion in Cell Biology, 1993The past year has seen significant advances in the biochemical, genetic and molecular dissection of the light signal transduction and developmental pathways that lead to photoregulated gene expression in higher plants. A major part of recent research has focused on the assignment of biological functions to the various photoreceptors, the genetic ...
H M, Li, T, Washburn, J, Chory
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Dietary regulation of gene expression
Current Opinion in Gastroenterology, 2004The intestine has traditionally been assumed to process food by digestion and absorption. The possibility that the intestine or other genes in the body respond to diet has only slowly been appreciated.This review examines recent evidence that nutrients act on genes in the intestine and in distant sites such as the brain, liver, and skeletal muscle. The
Rachel S, Levi, I R, Sanderson
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Regulation of erythropoietin gene expression
Current Opinion in Hematology, 1995The study of erythropoietin gene expression provides a paradigm for understanding gene regulation in response to hypoxia. The sensor for detecting alterations in oxygen tension appears to be a heme protein. Ongoing transcription and protein synthesis are necessary for hypoxic induction of erythropoietin messenger RNA.
L E, Huang, H F, Bunn
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Regulation of mammalian gene expression
2000The expression of mammalian genes is regulated primarily at the level of initiation of transcription. The regulatory structure of the mammalian genes consists of the sequence coding for a protein, a proximal upstream promoter sequence which binds the general (basal) transcription factors and a distant enhancer sequence which binds the inducible ...
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Regulation of chondrocyte gene expression
Frontiers in Bioscience, 1999Extracellular influences known to affect the regulation of chondrocyte biosynthetic and catabolic activity have been shown to include soluble factors, extracellular matrix and mechanical stress. A balance of these numerous extracellular influences is required for normal function of articular cartilage. It is likely that OA is the result of an imbalance
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Synthetic biology approaches in regulation of targeted gene expression
Current Opinion in Plant Biology, 2021Wusheng Liu
exaly
Epigenetic regulation of gene expression in response to environmental exposures: From bench to model
Science of the Total Environment, 2021, Zeqin Li
exaly