Before hormones: early sex-specific mechanisms shaping nervous system development, function, and postnatal disease susceptibility. [PDF]
Tsiarli MA, Larschan EN.
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Multiomic single-nucleus profiling reveals cell-type-specific epigenetic and transcriptional dysregulation in major depressive disorder brain. [PDF]
Francis A, Dwivedi Y.
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Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation. [PDF]
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Identification of candidate macrophage-ferroptosis crosstalk genes associated with immune infiltration in myocardial infarction: A bioinformatics analysis. [PDF]
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Transcriptome Sequencing Reveals Molecular Characteristics of Spinal Cord Degeneration in MPTP-Induced Parkinson's Disease Mice. [PDF]
Xiao L +7 more
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Genome-Wide Identification of the R2R3-MYB Gene Family in <i>Solanum americanum</i> and Functional Analysis of Its Role in Fruit Coloration. [PDF]
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Regulated Gene Expression in Gene Therapy
Annals of the New York Academy of Sciences, 2001Abstract: The original model of gene therapy, that of efficient delivery, durable transfer, and stable expression of transgenes to correct a gene defect underlying an inherited disease, is limited in light of improved understanding of the processes involved.
P W, Zoltick, J M, Wilson
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Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
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Dimerizer-regulated gene expression
Current Opinion in Biotechnology, 2002Control of gene expression using small molecules is a powerful research tool and has clinical utility in the context of regulated gene therapy. Use of chemical inducers of dimerization, or dimerizers, for this purpose has several advantages, including tight regulation, modularity to facilitate iterative improvements, and assembly from human proteins to
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