Results 231 to 240 of about 2,019,582 (297)

Regulated Gene Expression in Gene Therapy

Annals of the New York Academy of Sciences, 2001
Abstract: The original model of gene therapy, that of efficient delivery, durable transfer, and stable expression of transgenes to correct a gene defect underlying an inherited disease, is limited in light of improved understanding of the processes involved.
P W, Zoltick, J M, Wilson
openaire   +2 more sources

Regulation of Gene Expression

New England Journal of Medicine, 1994
Genetics is a language with rules of composition that give the tissues of the body their special traits. These rules govern the activation of particular subgroups of genes, which determine not only the unique characteristics of a cell type but also whether it remains quiescent, divides, or dies. The timing of gene activation is very important. If genes
openaire   +2 more sources

Dimerizer-regulated gene expression

Current Opinion in Biotechnology, 2002
Control of gene expression using small molecules is a powerful research tool and has clinical utility in the context of regulated gene therapy. Use of chemical inducers of dimerization, or dimerizers, for this purpose has several advantages, including tight regulation, modularity to facilitate iterative improvements, and assembly from human proteins to
Roy, Pollock, Tim, Clackson
openaire   +2 more sources

Home - About - Disclaimer - Privacy