Results 111 to 120 of about 7,080,207 (344)
A Comparison of Brain Gene Expression Levels in Domesticated and Wild Animals
PLoS Genetics, 2012 Domestication has led to similar changes in morphology and behavior in several animal species, raising the question whether similarities between different domestication events also exist at the molecular level.
F. W. Albert +13 more
semanticscholar +1 more source
Gene function contributes to gene expression levels inS. cerevisiae [PDF]
, 2018 ABSTRACTIt is not understood what evolutionary factors drive some genes to be expressed at a higher level than others. Here, we hypothesized that a gene’s function plays an important role in setting expression level. First, we established that eachS.
Hickman, Mark J. +4 more
openaire +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Relation of IGF-I and IGFBP5 gene expression levels in Schizophrenia patients
Van Tıp Dergisi, 2020 INTRODUCTION: Schizophrenia is a severe mental disorder affecting more than 21 million people worldwide. Disruptions of the GH-IGF-I axis likely lead to schizophrenia by causing deficits in early stages of neurodevelopment and low IGF-I levels are ...
Sevgi Karabulut Uzunçakmak +2 more
doaj +1 more source
BrainGENIE: The Brain Gene Expression and Network Imputation Engine
Translational Psychiatry, 2023 In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. To address this problem, we developed a computational method called the Brain Gene Expression and Network-Imputation Engine (BrainGENIE) that leverages
Jonathan L. Hess +10 more
doaj +1 more source
Transposon variants and their effects on gene expression in arabidopsis [PDF]
, 2013 Transposable elements (TEs) make up the majority of many plant genomes. Their transcription and transposition is controlled through siRNAs and epigenetic marks including DNA methylation.
Smith, L.M., Wang, X., Weigel, D.
core +3 more sources
TheScientificWorldJournal, 2012 Consistent biosynthesis of desired secondary metabolites (SMs) from pure microbial cultures is often unreliable. In a proof-of-principle study to induce SM gene expression and production, we describe mixed “co-culturing” conditions and monitoring of ...
C. Conway, N. Esiobu, J. V. Lopez
semanticscholar +1 more source
Analytical Biochemistry, 1996 The tetracycline-controlled gene expression system utilizes the control elements of the tetracycline resistance operon encoded in TnlO of Escherichia coli to control gene expression in eukaryotic cells. Here we demonstrate the quantitative control of the expression of the luciferase gene, dihydrofolate reductase gene, and bcl-2 gene in HeLa S3 or ...
D X, Yin, L, Zhu, R T, Schimke
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Patologìâ, 2018 Aim – analysis of CDH1 and CTNNB1 genes mRNA expression levels and expression levels of E-cadherin, β-catenin proteins coded by these genes, and also their correlations with KRAS gene transcriptional activity level on the I, II, III, IV stages (pTNM) of ...
M. A. Shyshkin , V. O. Tumanskyi
doaj +1 more source