Results 161 to 170 of about 12,165,430 (302)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fuzzy Clustering Models for Gene Expression Data Analysis [PDF]

With the advent of microarray technology, it is possible to monitor gene expression of tens of thousands of genes in parallel. In order to gain useful biological knowledge, it is necessary to study the data and identify the underlying patterns, which ...
Wang, Yu
core  

NLRP3 and RANK-RANKL-OPG Pathway-related Gene Expression Levels in Children With Autism Spectrum Disorder. [PDF]

In Vivo
Kara B, Savaş M, Özer T, Şişmanlar ŞG, Akarsu R, Öztürk SY, Akpinar ŞN, Deniz A, Güneş AS, Dursun F, Akkoyunlu DS, Çine N, Tüzün E.   +12 more
europepmc   +1 more source

INDOLEAMINE-2,3-DIOXYGENASE GENE EXPRESSION LEVELS IN RESPONSE TO CHRONIC HEPATITIS B VIRUS INFECTION IN ZARIA, NIGERIA. [PDF]

Niger J Immunol, 2023
Ahmad AE, Bakari AG, Musa BOP, Mustapha SK, Yusuf BJ, Abdullahi IN, Tahir MI, Afolaranmi TO, Hawkins C, Sagay AS, Muktar HM, Usman Y, Anka AU, Olayinka AT.   +13 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

RNA-Seq Can Be Used to Quantify Gene Expression Levels for Use in the GARDskin Assay. [PDF]

Toxics
Gradin R, Andersson J, Forreryd A, Johansson H.   +3 more
europepmc   +1 more source

Overexpression of RuFLS2 Enhances Flavonol-Related Substance Contents and Gene Expression Levels. [PDF]

Int J Mol Sci, 2022
Huang X, Wu Y, Zhang S, Yang H, Wu W, Lyu L, Li W.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Upregulation of senescence-associated gene expression levels in human gingival tissue affected by periodontitis. [PDF]

J Periodontol
Kim SJ, Batra C, Yoshii H, Hamada Y, Ueki Y, Eckert GJ, John V, Kittaka M.   +7 more
europepmc   +1 more source

The Association of Ketolytic Enzymes Gene Expression Levels with Mitochondrial Activity and Content in Oral Squamous Cell Carcinoma [PDF]

Asian Pac J Cancer Prev, 2022
Yousefi M, Karimi A, Goudarzi A.
europepmc   +1 more source