Results 171 to 180 of about 12,165,430 (302)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Gene Expression Levels of Ferroptosis Suppressor Protein (<i>FSP1</i>) and Ferroptosis Inducer (<i>ACSL4</i>) and Their Correlation With Clinicopathological Features in Colorectal Cancer Patients. [PDF]

Health Sci Rep
Fardsanei A, Goodarzi MT, Agah S, Izadinia J, Akbari A.   +4 more
europepmc   +1 more source

Intestinal segment and vitamin D₃ concentration affect gene expression levels of calcium and phosphorus transporters in broiler chickens. [PDF]

J Anim Sci Technol, 2023
Han J, Wu L, Lv X, Liu M, Zhang Y, He L, Hao J, Xi L, Qu H, Shi C, Li Z, Wang Z, Tang F, Qiao Y.   +13 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Impacts of Metabolic Reprogramming on the Onset of Diabetic Nephropathy in Mice With Varying Lias Gene Expression Levels. [PDF]

Diabetes
Li S, Zhou J, Wallace ED, Ehrmann BM, Homeister JW, James LR, Maeda N, Jia Z, Yi X.   +8 more
europepmc   +1 more source

Gene Expression Levels of CSF-1 and CSF-1R Endometrial under The Influence of Prolactin Level in Unexplained Miscarriage: A Case-Control Study. [PDF]

Int J Fertil Steril, 2023
Sadeghi Jam Z, Tahmasebi Fard Z.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Expression levels of microRNA machinery components Drosha, Dicer and DGCR8 in human (AGS, HepG2, and KEYSE-30) cancer cell lines [PDF]

: MicroRNAs (miRNAs) have recently been shown to play fundamental roles in diverse cellular processes and linked to variety of cancers. Dicer and Drosha are tw major enzymes in the miRNA maturation process.
حسینی اصل, سید سعید, جعفری, ناصر, ایانگ, گلن, شیرزاد, زهره, پیری دوگاهه, هادی, علی بیکی, فاطمه, زرگر, سید جلال, بهلولی, شهاب   +7 more
core  

Mot1 regulation of promoter binding by TBP varies with stress and gene expression levels independently of coactivator dependence. [PDF]

Proc Natl Acad Sci U S A
Mittal P, Hinnebusch AG.
europepmc   +1 more source

Evaluation of IL-4, MIP-1α, and MMP-9 gene expression levels in peri-implant tissues in peri-implantitis. [PDF]

Braz Dent J, 2023
Giro G, Taira J, Andriani F, Watinaga S, Bastos MF, Shibli JA.   +5 more
europepmc   +1 more source