Results 81 to 90 of about 7,080,207 (344)

Addendum: Precise tuning of gene expression levels in mammalian cells

Nature Communications, 2019
Following re-sequencing of the miSFIT constructs used in the paper, two of the construct variants inserted into the 3’UTR of PD-1, namely ‘12C’ and ‘17A, 18G’, have been found to contain additional insertions not present in the other construct variants ...
Yale S. Michaels, Mike B. Barnkob, Hector Barbosa, Toni A. Baeumler, Mary K. Thompson, Violaine Andre, Huw Colin-York, Marco Fritzsche, Uzi Gileadi, Hilary M. Sheppard, David J. H. F. Knapp, Thomas A. Milne, Vincenzo Cerundolo, Tudor A. Fulga   +13 more
doaj   +1 more source

Heavy alcohol drinking downregulates ALDH2 gene expression but heavy smoking up-regulates SOD2 gene expression in head and neck squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background This study aims to determine the relationship between expression levels of ALDH2 and SOD2 genes and clinical parameters such as alcohol drinking, tobacco smoking, primary site of HNSCC, and human papilloma virus (HPV) state.
Dong Jin Lee, Hyung Min Lee, Jin Hwan Kim, II Seok Park, Young Soo Rho   +4 more
doaj   +1 more source

Towards a digital model of zebrafish embryogenesis. Integration of Cell Tracking and Gene Expression Quantification [PDF]

, 2010
We elaborate on a general framework composed of a set of computational tools to accurately quantificate cellular position and gene expression levels throughout early zebrafish embryogenesis captured over a time-lapse series of in vivo 3D images.
Bourgine, Paul, Castro González, Carlos, Desnoulez, Sophie, Douloquin, Louise, Ledesma Carbayo, María Jesús, Luengo Oroz, Miguel Ángel, Melani, Camilo, Peyrieras, Nadine, Santos Lleo, Andres de, Savy, Thierry   +9 more
core   +1 more source

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression [PDF]

, 2019
Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role.
't Hoen, Peter-Bram, Amin, Najaf, Arindrarto, Wibowo, Beekman, Marian, Boezen, H Marike, Bonder, Marc Jan, Boomsma,, Dorret I, Bot, Jan, Brusselle, Guy, de Jong, Kim, de Vries, Maaike, Deelen, Joris, Deelen, Patrick, Franke, Lude, Heijmans, Bastiaan T, Hoen, Peter ACT, Hofman, Bert A, Hottenga, Jouke J, Isaacs, Aaron, Jansen, Rick, Jhamai, P Mila, Kielbasa, Szymon M, Kromhout, Hans, La Bastide-van Gemert, Sacha, Lahousse, Lies, Lakenberg, Nico, Luijk, Rene, Mei, Hailiang, Moed, Matthijs, Nedeljkovic, Ivana, Nooren, Irene, Pool, Rene, Postma, Dirkje S, Schalkwijk, Casper G, Slagboom, P Eline, Stehouwer, Coen DA, Suchiman, H Eka D, Swertz, Morris A, Terzikhan, Natalie, Tigchelaar, Ettje E, Uitterlinden, Andre G, van den Berg, Leonard H, van Der Breggen, Ruud, van Der Kallen, Carla JH, van Der Plaat, Diana, van Diemen, Cleo C, van Dijk, Freerk, van Dongen, Jenny, van Duijn, Cornelia M, van Galen, Michiel, van Greevenbroek, Marleen MJ, van Heemst, Diana, van Iterson, Maarten, van Meurs, Joyce, van Rooij, Jeroen, van Zwet, Erik W, Vant Hof, Peter, Veldink, Jan H, Verbiest, Michael, Verkerk, Marijn, Vermaat, Martijn, Vermeulen, Roel CH, Vonk, Judith M, Wijmenga, Cisca, Zhernakova, Dasha V, Zhernakova, Sasha   +65 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Ameliorative effects of strigolactone on tolerance to lead stress on lettuce (Lactuca sativa L.) plants

Scientific Reports
Soil contamination by heavy metals, particularly lead (Pb), which is considered the second most toxic metal, poses serious risks to plants and humans due to its accumulation from various anthropogenic activities. Strigolactones (SLs) are a novel class of
Sumeyra Ucar, Merve Yuce, Esma Yigider, Murat Aydin, Metin Turan, Melek Ekinci, Emre Ilhan, Ayse Gul Kasapoglu, Melike Akca, Firuze Oztemiz, Guleray Agar, Ertan Yildirim   +11 more
doaj   +1 more source

Effects of Flight on Gene Expression and Aging in the Honey Bee Brain and Flight Muscle [PDF]

, 2012
Honey bees move through a series of in-hive tasks (e.g., “nursing”) to outside tasks (e.g., “foraging”) that are coincident with physiological changes and higher levels of metabolic activity.
Ammons, Andrew, Benito, Azucena A., Elekonich, Michelle M., Mancinelli, Georgina E., Margotta, Joseph, Roberts, Stephen P.   +5 more
core   +5 more sources

The Contribution of RNA Decay Quantitative Trait Loci to Inter-Individual Variation in Steady-State Gene Expression Levels

PLoS Genetics, 2012
Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gene ...
A. Pai, Carolyn E. Cain, Orna Mizrahi-Man, Sherryl De Leon, Noah Lewellen, Jean-Baptiste Veyrieras, J. Degner, Daniel J. Gaffney, Joseph K. Pickrell, M. Stephens, J. Pritchard, Y. Gilad   +11 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Manipulating the Prion Protein Gene Sequence and Expression Levels with CRISPR/Cas9. [PDF]

PLoS ONE, 2016
The mammalian prion protein (PrP, encoded by Prnp) is most infamous for its central role in prion diseases, invariably fatal neurodegenerative diseases affecting humans, food animals, and animals in the wild.
Lech Kaczmarczyk, Ylva Mende, Branko Zevnik, Walker S Jackson   +3 more
doaj   +1 more source