Results 101 to 110 of about 620,853 (205)

The CRISPR-dCas9 interference system suppresses inhA gene expression in Mycobacterium smegmatis

open access: yesScientific Reports
CRISPR-dead Cas9 interference (CRISPRi) has become a valuable tool for precise gene regulation. In this study, CRISPRi was designed to target the inhA gene of Mycobacterium smegmatis (Msm), a gene necessary for mycolic acid synthesis.
Nuntita Singpanomchai   +1 more
doaj   +1 more source

Unveiling the orchestration: mycobacterial small RNAs as key mediators in host-pathogen interactions

open access: yesFrontiers in Microbiology
Small RNA (sRNA) molecules, a class of non-coding RNAs, have emerged as pivotal players in the regulation of gene expression and cellular processes.
Rajni Garg   +2 more
doaj   +1 more source

A novel transcriptional regulator, CdeR, modulates the type III secretion system via c-di-GMP signaling in Dickeya dadantii

open access: yesMicrobiology Spectrum
Dickeya dadantii is a bacterial pathogen that causes soft rot disease in many plant species worldwide, including temperate, subtropical, and tropical regions. This bacterium employs the type III secretion system (T3SS) to manipulate host immune responses.
Alaleh Ghasemi   +2 more
doaj   +1 more source

Transcription factor shapes chromosomal conformation and regulates gene expression in bacterial adaptation

open access: yesNucleic Acids Research
Abstract Genomic mutations allow bacteria to adapt rapidly to adverse stress environments. The three-dimensional conformation of the genome may also play an important role in transcriptional regulation and environmental adaptation. Here, using chromosome conformation capture, we investigate the high-order architecture of the Zymomonas ...
Mao Chen   +10 more
openaire   +2 more sources

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