Results 191 to 200 of about 651,815 (307)

Ammonia Stress Disrupts Intestinal Health in <i>Litopenaeus vannamei</i> Under Seawater and Low-Salinity Environments by Impairing Mucosal Integrity, Antioxidant Capability, Immunity, Energy Metabolism, and Microbial Community. [PDF]

Antioxidants (Basel)
Duan Y, Nan Y, Li J, Xiao M, Wang Y, Zhu R.   +5 more
europepmc   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Carbon source-driven downregulation of the sRNA AmiL enhances <i>Pseudomonas aeruginosa</i> virulence during acute lung infection. [PDF]

Virulence
Jing W, Li M, Huang S, He X, Wu Y, Long J, Zhang S, Lin C, Xiao Q, Zeng J, Shen C, Chen C, Pu J.   +12 more
europepmc   +1 more source

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Two-component systems as potential therapeutic targets in <i>Neisseria</i> pathogenesis. [PDF]

Ann Med
Haldar T, Saroj SD.
europepmc   +1 more source

Gentamicin‐Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

Advanced Healthcare Materials, EarlyView.
A bone substitute with gentamicin physically precipitated onto the surface of carbonate apatite exhibits prompt drug release, high bactericidal activity, and osteogenic capacity. Efficient antibacterial activity mitigates early postoperative neutrophil accumulation, the status of which may serve as a potential parameter for evaluating the antibacterial
Linghao Xiao, Gabriela Laranjeira Abe, Jun‐Ichi Sasaki, Haruaki Kitagawa, Ririko Tsuboi, Tomoki Kohno, Satoshi Imazato   +6 more
wiley   +1 more source

Genomic and Transcriptomic Dissection of Growth Characteristics and Exopolysaccharide-Related Bioactivities in <i>Lactiplantibacillus plantarum</i> NMGL2. [PDF]

Foods
Wang Y, Bao X, Yang Z, Han D.
europepmc   +1 more source

DNA topology and the global control of bacterial gene expression: implications for the regulation of virulence gene expression [PDF]

Microbiology, 1995
openaire   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Bioinformatics Analysis of the Tomato <i>SlPR5</i> Gene Family and the Thaumatin-like Protein SlPR5-3 Positively Regulates Tomato Resistance to <i>Pst</i> DC3000. [PDF]

Plants (Basel)
Pang X, Wang Y, Jiang B, Li D, Zhang H, Liu D, Xu X, Zhao T.   +7 more
europepmc   +1 more source