Results 221 to 230 of about 7,007,953 (262)

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

Phytotherapy Research, EarlyView.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo, Paola Lasso, Claudia Urueña, Susana Fiorentino   +3 more
wiley   +1 more source

Lineage master regulator and cancer-selective partner transcription factors rewire 3D genome topology for tumor-specific gene control. [PDF]

Sci Adv
Jung N, Lopez-Pajares V, Donohue LKH, Guo MG, Srinivasan S, Siprashvili Z, Khavari PA.   +6 more
europepmc   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Comparative Functional Effects of Abemaciclib and Arcyriaflavin A in <i>MYCN</i>-Amplified and Non-Amplified Neuroblastoma Cells: An Exploratory Transcriptomic Study. [PDF]

Int J Mol Sci
Çerçi B, Karahan Hİ, Soyöz M, Pehlivan M, Pirim İ.   +4 more
europepmc   +1 more source

Apigenin Protects Hypertensive Intracerebral Hemorrhage by Regulating Trx1 Through Binding to PRDX2

Phytotherapy Research, EarlyView.
ABSTRACT Intracerebral hemorrhage (ICH) remains the most severe stroke subtype with high mortality and disability rates. Although apigenin has shown cerebroprotective potential in preclinical studies, its mechanism of action, particularly in hypertensive ICH, remains poorly understood.
Hao‐chen Xu, Ming Liu, Ying‐ying Sun, Jie‐Dan Ping, Qing‐hua Cui, Jing‐zhou Chen, Hao Li   +6 more
wiley   +1 more source

Role of EMP2 and Del-1 in Tamoxifen-resistant Breast Cancer Cells. [PDF]

In Vivo
Lee IH, Kang J, Lee J, Kang B, Moon JS, Park HY, Kim EA, Jeong SH, Chae YS, Lee SJ.   +9 more
europepmc   +1 more source

Schisandrin C Targets PPARγ to Induce Ferroptosis in Colorectal Cancer Cells and Promote M1 Macrophage Polarization

Phytotherapy Research, EarlyView.
Schisandrin C: A Dual Anti‐Colorectal Cancer Strategy Targeting PPARγ. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer mortality, necessitating novel therapeutic strategies. Schisandrin C (SinC), a bioactive lignan from Schisandra chinensis, exhibits diverse pharmacological activities, but its anti‐CRC mechanisms are poorly ...
Xiao Wei, Hong‐Ping Wen, Jian‐Bo Song, Jin‐Fang Xu, Hong‐Rui Guo   +4 more
wiley   +1 more source

The TCN1 Paradox: Unraveling the Dual Role of Transcobalamin I in Colorectal Cancer-From Metabolic Regulation to Oncogenic Signaling. [PDF]

Cancer Manag Res
Zhu X, Ge B, Shan S, Wen L.
europepmc   +1 more source

Integrated transcriptomic profiling reveals immune and molecular stage-specific signatures of colorectal cancer in hispanics living in Puerto Rico. [PDF]

Front Immunol
Zenón-Meléndez CN, López-Acevedo SN, Pérez-Santiago J, Ortíz-Maldonado YN, Centeno-Girona H, Caraballo-Rivera EV.   +5 more
europepmc   +1 more source

Quantitative and Targeted Regulation of Ferroptosis in Bladder Cancer: Preclinical Study. [PDF]

J Cell Mol Med
Dong Y, Xu C, Yan B, Mou S, Li C, Liu Y.
europepmc   +1 more source