Results 201 to 210 of about 7,007,953 (262)

Triptolide Suppresses Tongue Squamous Cell Carcinoma Progression via PI3K–AKT Pathway Inhibition: An Integrative Network Pharmacology and Experimental Validation Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Tongue squamous cell carcinoma, the most aggressive subtype of oral squamous cell carcinoma, which is associated with high mortality, frequent recurrence, and early lymph‐node metastasis. Triptolide, a bioactive diterpenoid from Tripterygium wilfordii, exhibits broad anticancer activity.
Shan‐Shan Wang, Hong‐Cheng Wei, Lin Jiang, Yi‐Sen Shao   +3 more
wiley   +1 more source

Single-Cell Transcriptomic Analysis Reveals Ferroptosis-Related Signatures and Tumor Microenvironment Heterogeneity in Epithelial Ovarian Cancer. [PDF]

Cancer Med
Liu J, Li J, Li B, Liang H.
europepmc   +1 more source

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Unveiling differential gene expression and pathways in clear cell renal cell carcinoma with sarcomatoid transformation. [PDF]

PeerJ
Foong YX, Yap NY, Mun KS, Gobe G, Kuppusamy S, Ong TA, Rajandram R.   +6 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Editorial: Epigenetic regulation in cancer: mechanisms, implications, and therapeutic interventions. [PDF]

Front Cell Dev Biol
Sparaneo A, Chan AKN, Fabrizio FP.
europepmc   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Decoding lactylation heterogeneity in glioblastoma: machine learning identifies G6PC3 as a prognostic target. [PDF]

BMC Cancer
Liu Y, Deng H, Song P, Qiu Q, Bu J, Zhang M.   +5 more
europepmc   +1 more source

Differential Transcriptome Analysis of Lung Squamous Cell Carcinoma Under Different RUNX3 Expression Patterns

Medicine Advances, EarlyView.
RUNX3 status in lung squamous cell carcinoma (LUSC) is associated with subtle gene‐level differences but reveals exploratory pathway‐level patterns, including epithelial differentiation, extracellular matrix remodeling, and hypoxia‐related programs. These findings generate testable hypotheses for RUNX3's biological role in LUSC.
Weibin Liu, Xiaobin Zheng, Jianqing Zheng, Yujie Deng, Bifen Huang, Weijin Xiao, Jiarong Zhang, Xuejin Zheng, Xinlong Zheng, Gen Lin, Xiaohui Chen   +10 more
wiley   +1 more source

Tceal7 is a BRG1-regulated target of calcineurin signaling that promotes myoblast differentiation. [PDF]

PLoS One
Yadav S, Sharma T, Olea-Flores M, Padilla-Benavides T, Imbalzano AN.   +4 more
europepmc   +1 more source