Results 71 to 80 of about 668,253 (275)

Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer

BMC Cancer, 2007
Background Ovarian cancer (OvCa) most often derives from ovarian surface epithelial (OSE) cells. Several lines of evidence strongly suggest that increased exposure to progesterone (P4) protects women against developing OvCa.
DeLoia Julie A, Hsu Lih-Ching, Willett-Brozick Joan E, Feddes Grace O, Wilcox Cathy B, Baysal Bora E   +5 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

MiR-200c restoration inhibits FOXP3 and metastatic spread in breast cancer: evidence from in vitro and in vivo models

BMC Cancer
Background Metastatic breast cancer remains a leading cause of cancer-related mortality in women, often driven by molecular pathways that promote invasion and immune evasion.
Nashwa El-Khazragy, Ahmed Alsolami, Ahmed M. Aref, Marwa N. M. Hassan, Mohamed S. Othman   +4 more
doaj   +1 more source

Emerging roles of telomeric chromatin alterations in cancer [PDF]

, 2019
Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria, Cacchione, Stefano, Rizzo, Angela   +2 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

COX-2 gene expression and methylation profile in Sapajus apella as an experimental model for gastric adenocarcinoma

Genetics and Molecular Biology, 2018
Gastric cancer (GC) remains one of the main causes of cancer-related death worldwide. There are two distinct histological types of GC: diffuse and intestinal. The latter is characterized by the presence of pre-neoplastic lesions.
Danilo do Rosário Pinheiro, Maria Lucia Harada, Rommel Mario Rodriguez Burbano, Barbara do Nascimento Borges   +3 more
doaj   +1 more source

The impact of caffeic acid phenethyl ester, chrysin and ethanolic extracts of propolis on PLD1 gene expression in AGS cell line [PDF]

Journal of HerbMed Pharmacology, 2019
Introduction: Up-regulation of phospholipase D (PLD) is functionally related to tumorigenesis and oncogenic signals. Chrysin, caffeic acid phenethyl ester (CAPE) and ethanolic extract of propolis (EEP) are three safe compounds which have been shown to ...
Hamideh Jafari-Ghahfarokhi, Ali Jazaeri, Nematallah Amini-Sarteshnizi, Hossein Teimori   +3 more
doaj   +1 more source

A taxonomy of epithelial human cancer and their metastases [PDF]

, 2009
Background: Microarray technology has allowed to molecularly characterize many different cancer sites. This technology has the potential to individualize therapy and to discover new drug targets.
Olivier Gevaert, Anneleen Daemen, Bart De Moor, Louis Libbrecht, CH Chung, TR Golub, B Weigelt, T Sorlie, DN Hayes, CM Perou, A Bhattacharjee, A Alizadeh, T Sorlie, S Ramaswamy, TJ Giordano, D Rhodes, S Ramaswamy, GV Glinsky, N Pavlidis, RW Tothill, RA Bender, G Bloom, XJ Ma, D Talantov, CL Wilson, M Dai, A Subramanian, G Dennis, DW Huang, PS Nelson, M Cuatrecasas, JH Eichhorn, SK Tickoo, G Ayala, J Brugarolas, P Staller, X Liu, BJ Yoder, M Lacroix, B Weigelt, C Sotiriou, EA Rakha, C Sotiriou, AV Ivshina, M Ignatiadis, JX Yu, Z Hu, EK Sloan, AK Witkiewicz, L Lukes, AK Witkiewicz, XJ Ma, K Pavlakis, S Troup, K Wennmalm, P Schedin, G Finak, KA Oien, HG Laberke, MB Amin, SJ Jung, RC Bast Jr, JD Seidman, H Kang, H Naora, SM Smorenburg, T Sukata, IJ Matouk, S Khambata-Ford, MA Pantaleo, DH Ki, A Ramasamy, M Snyder, J Belmont, K Chin, LD Miller, J Pittman   +76 more
core   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Up-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signaling. [PDF]

PLoS ONE, 2009
BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses.
Jean Ndjomou, In-woo Park, Ying Liu, Lindsey D Mayo, Johnny J He   +4 more
doaj   +1 more source