Up-regulation of hepatitis C virus replication and production by inhibition of MEK/ERK signaling. [PDF]
PLoS ONE, 2009 BACKGROUND: Viruses interact with and exploit the host cellular machinery for their multiplication and propagation. The MEK/ERK signaling pathway positively regulates replication of many RNA viruses.
Jean Ndjomou +4 more
doaj +1 more source
Thyroid status modulates T lymphoma growth via cell cycle regulatory proteins and angiogenesis [PDF]
, 2014 We have shown in vitro that thyroid hormones (THs) regulate the balance between proliferation and apoptosis of T lymphoma cells. The effects of THs on tumor development have been studied, but the results are still controversial.
Barreiro Arcos, María Laura +10 more
core +1 more source
PMAIP1 promotes J subgroup avian leukosis virus replication by regulating mitochondrial function
Poultry Science: Avian leukosis virus Subgroup J (ALV-J) exhibits high morbidity and pathogenicity, affecting approximately 20% of poultry farms. It induces neoplastic diseases and immunosuppression.
Yongxia Zhao +8 more
doaj +1 more source
AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone
Biochemistry Research International, 2011 Matrix-metalloproteinase-13 (MMP-13) has been shown to be an important protease in inflammatory and neoplastic conditions of the skeletal system. In particular, the stromal cells of giant cell tumor of bone (GCT) express very high levels of MMP-13 in ...
Isabella W. Y. Mak +4 more
doaj +1 more source
Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]
, 2016 The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela +5 more
core +1 more source
Papillomavirus E5: the smallest oncoprotein with many functions [PDF]
, 2011 Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Borzacchiello, G. +6 more
core +4 more sources
Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]
, 2015 SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo +20 more
core +3 more sources
Vitamin D enzymes (CYP27A1, CYP27B1 and CYP24A1) and receptor expression in non-melanoma skin cancer [PDF]
, 2019 No abstract available for this ...
Apostolopoulos, Vasso +4 more
core +2 more sources
Nothing in excess - lessons learned from the expression of high-mobility group proteins type A in non-cancer and cancer cells [PDF]
, 2011 High-mobility group A (HMGA) proteins are major transcription regulators which are abundantly and ubiquitously expressed in undifferentiated cells but present at a low level in somatic cells of adult organisms.
Petkova, Rumena +2 more
core +3 more sources
Pan-Cancer analysis of the expression and regulation of matrisome genes across 32 tumor types
Matrix Biology Plus, 2019 The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines and growth factors collectively referred to as the matrisome.
Valerio Izzi +6 more
doaj +1 more source