Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Splayed : a chromatin remodeler regulating tissue specific gene silencing and developmental timing [PDF]
, 2014 A number of mechanisms that contribute to epigenetic regulation of gene expression have been described in plants. The concert actions of these mechanisms contribute to proper patterning of gene expression within organs and tissues, therefore insuring ...
Fal, Kateryna
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Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Functional mapping of pea legumin upstream regulatory elements using TI plasmid vectors [PDF]
, 1991 The leg A gene from Pisum sativum L. has been extensively characterised and a distinct pattern of developmental and organ-specific gene expression demonstrated.
Garrett, Christine, Garrett, C
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Editorial: Bioinformatics of Genome Regulation, Volume II
Frontiers in Genetics, 2021 Yuriy L. Orlov +6 more
doaj +1 more source
Frontiers in Plant ScienceAccurate prediction of plant gene expression is essential for elucidating the regulatory mechanisms underlying plant development and stress adaptation.
Fei Guo +4 more
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Arabidopsis thaliana DOF6 negatively affects germination in non-after ripened seeds and interacts with TCP14 [PDF]
, 2011 Seed dormancy prevents seeds from germinating under environmental conditions unfavourable for plant growth and development and constitutes an evolutionary advantage.
Barrero Sicilia, Cristina +4 more
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Transcriptional and post-transcriptional regulation of gene expression in plants [PDF]
, 1992 In the past few years virtually every aspect of plant gene expression has been covered by thoughtful, in-depth reviews. In this article, it is not my goal to repeat, combine or update those reviews.
Kuhlemeier, Cris
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Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source