Results 101 to 110 of about 267,816 (318)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Short Indel-Lacking-Resistance Gene Triggers Silencing of the Photosynthetic Machinery Components Through TYLCSV-Associated Endogenous siRNAs in Tomato

Frontiers in Plant Science, 2018
Plant viruses modify gene expression in infected tissues by altering the micro (mi)RNA-mediated regulation of genes. Among conserved miRNA targets there are transcripts coding for transcription factors, RNA silencing core, and disease-resistance proteins.
Michela Chiumenti, Claudia Rita Catacchio, Laura Miozzi, Walter Pirovano, Mario Ventura, Vitantonio Pantaleo   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Editorial: Bioinformatics of Genome Regulation, Volume II

Frontiers in Genetics, 2021
Yuriy L. Orlov, Yuriy L. Orlov, Anastasia A. Anashkina, Anastasia A. Anashkina, Tatiana V. Tatarinova, Ancha V. Baranova, Ancha V. Baranova   +6 more
doaj   +1 more source

MTMixG-Net: mixture of Transformer and Mamba network with a dual-path gating mechanism for plant gene expression prediction

Frontiers in Plant Science
Accurate prediction of plant gene expression is essential for elucidating the regulatory mechanisms underlying plant development and stress adaptation.
Fei Guo, Wenjuan Li, Aihong Lu, Rongzhen Feng, Wu Fang   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Take control of expression: effector-mediated modulation of the host transcriptional machinery

Frontiers in Plant Science
Interactions between plants and microbes that colonize them typically result in significant alterations of the host’s gene expression. Such transcriptional changes include modulation of immune responses, as well as orchestrating metabolic and ...
Weiliang Zuo, Muye Xiao, Gunther Doehlemann   +2 more
doaj   +1 more source

Transcriptional profiling of plant embryogenesis. [PDF]

, 2005
The process of embryogenesis in higher plants is a critical stage of the sporophytic life cycle, transforming the fertilised egg cell via a precise sequence of events into a multi-cellular organism.
Spencer, Matthew William Beresford
core  

The Pisum sativum SAD short-chain dehydrogenase/reductase: quinone reduction, tissue distribution, and heterologous expression [PDF]

, 2011
The pea (Pisum sativum) tetrameric short-chain alcohol dehydrogenase-like protein (SAD) family consists of at least three highly similar members (SAD-A, -B, and -C).
Hilja Strid, Strid, Hilja, Eriksson, Leif A.,, Nikolai Scherbak, Åke Strid, Strid, Hilja,, Anneli Ala-Häivälä, Böwer, Nathalie, Strid, Åke, Grahn, Elin M., Brosché, Mikael, Ala-Häivälä, Anneli, Gittins, John R.,, Elin Grahn, Mikael Brosché, John R. Gittins, Strid, Åke,, Grahn, Elin, Nathalie Böwer, Gittins, John R., Scherbak, Nikolai,, Eriksson, Leif A., Leif A. Eriksson, Grahn, Elin M.,, Scherbak, Nikolai, Brosché, Mikael,   +25 more
core   +1 more source