Results 81 to 90 of about 9,282,578 (312)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Quantitative analysis of cell-type specific gene expression in the green alga Volvox carteri [PDF]

, 2006
Nematollahi G, Kianianmomeni A, Hallmann A. Quantitative analysis of cell-type specific gene expression in the green alga Volvox carteri. BMC Genomics. 2006;7(1): 321.Background: The multicellular alga Volvox carteri possesses only two cell types: mortal,
Kianianmomeni Arash, Kianianmomeni, Arash, Hallmann Armin, Hallmann, Armin ; https://orcid.org/, Nematollahi, Ghazaleh, Nematollahi Ghazaleh, Arash Kianianmomeni, Armin Hallmann, Ghazaleh Nematollahi   +8 more
core   +1 more source

Research progress of nanomaterials in plant genetic transformation

上海师范大学学报. 自然科学版
Plant genetic transformation is crucial for improving quality of crop straits, cultivating new varieties with high yield, improved quality, and multi-resistance, thereby reducing the use of pesticides and fertilizers.
YANG Demin, CAO Tingting, LYU Min, CHEN Nan   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Identification of hepatocyte nuclear proteins wich interact with the human C-reactive promoter

, 1989
Regulation of Human C-reactive protein gene ...
Ciliberto G, Ganter U, Majello B, Arpaia G, Toniatti C., ARCONE, Rosaria   +5 more
core  

Gene expression regulation in allopolyploid fish [PDF]

, 2019
Plants, invertebrates and even lower vertebrates are known to deal with hybridization and polyploidy very successfully, surpassing the genetic constrains those phenomena bring.
Matos, Isa
core  

Gene induction during plant-microbe interactions : the role of chitinases during fungal infection and the investigation of mycorrhiza-induced genes in the model plant "M. truncatula" [PDF]

, 2007
In this thesis, the model legume Medicago truncatula was used for research on plant-microbe interactions. Unlike most other plants, legumes are able to form two distinct root symbioses. Together with soil-borne fungi of the Glomeromycota, they form the
Feddermann Bühler, Nadja
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source